{"product_id":"recombinant-mouse-ccl4-mip-1β-protein-rp01907","title":"Recombinant Mouse CCL4\/MIP-1β Protein - RP01907","description":"\u003cp\u003eRecombinant Mouse CCL4\/MIP-1β Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10ug, 20g, 50ug, 100ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RP01907-10, RP01907-20, RP01907-50, RP01907-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Recombinant Mouse CCL4\/MIP-1β Protein is produced by Pichia expression system. The target protein is expressed with sequence (Ala24-Asn92) of Mouse CCL4\/MIP-1β (Accession #NP_038680.1) fused with a His tag at the C-terminus.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: Ccl4, Mip1b, Scya4, C-C motif chemokine 4, Immune activation protein 2, ACT-2, ACT2, Macrophage inflammatory protein 1-beta, MIP-1-beta, Protein H400, SIS-gamma, Small-inducible cytokine A4\u003c\/p\u003e\n\n\u003cp\u003eSWISS: P14097\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 20303\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Mouse\u003c\/p\u003e\n\n\u003cp\u003ePurity: ≥ 90 % as determined by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20 ℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\n\u003cp\u003eBackground: CCL4, also known as macrophage inflammatory protein 1 beta (MIP-1 beta ), is a 12 kDa beta chemokine that is secreted at sites of inflammation by activated leukocytes, lymphocytes, vascular endothelial cells, and pulmonary smooth muscle cells. CCL4 attracts a variety of immune cells to sites of microbial infection as well as to other pathologic inflammation such as allergic asthma and ischemic myocardium. A CCL4 deficiency in mice promotes the development of autoantibodies, possibly as a result of compromised regulatory T cell recruitment. CCL4 is secreted from activated monocytes as a heterodimer with CCL3\/MIP-1 alpha. The first two N-terminal amino acids can be cleaved from human CCL4 by CD26\/DPPIV. Both the full length and truncated forms exert biological activity through CCR5, Both forms of CCL4 block HIV-1 infection of T cells by inducing the downregulation of CCR5.\u003c\/p\u003e\n\n\u003cp\u003eSource: Pichia\u003c\/p\u003e\n\n\u003cp\u003eTag: C-His\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.\u003c\/p\u003e\n\n\u003cp\u003eAntigen Sequence: APMGSDPPTSCCFSYTSRQLHRSFVMDYYETSSLCSKPAVVFLTKRGRQICANPSEPWVTEYMSDLELN\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1 EU\/μg of the protein by LAL method.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"10ug","offer_id":45198272397491,"sku":"RP01907-10","price":210.0,"currency_code":"CAD","in_stock":true},{"title":"20ug","offer_id":45198272430259,"sku":"RP01907-20","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"50ug","offer_id":45198272463027,"sku":"RP01907-50","price":350.0,"currency_code":"CAD","in_stock":true},{"title":"100ug","offer_id":45198272495795,"sku":"RP01907-100","price":560.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_94a7a565-96d1-4ac9-a95e-55a1e6ca2bea.png?v=1766959971","url":"https:\/\/afsbio.com\/products\/recombinant-mouse-ccl4-mip-1%ce%b2-protein-rp01907","provider":"AFSBio Inc.","version":"1.0","type":"link"}