{"product_id":"recombinant-mouse-cd6-tp120-protein-fc-tagactive-pksm040530","title":"Recombinant Mouse CD6\/TP120 Protein (Fc Tag)(Active) - PKSM040530","description":"Recombinant Mouse CD6\/TP120 Protein (Fc Tag)(Active)\n\nSize: 100μg\n\nCatalogue Number: PKSM040530-100\n\nCitations, Manuals and MSDS Available upon request.\n\nAbbreviation: CD6; TP120\n\nTarget Symptom: CD6 antigen; Cd6\n\nTarget Species: Mouse\n\nExpression Host: HEK293 Cells\n\nApplication: Cell culture; ELISA\n\nFusion Tag: C-hFc\n\nUNIProt ID: Q91WN5\n\nAccession: Q91WN5\n\nBackground: T-cell differentiation antigen CD6, also known as TP120 and CD6, is a single-pass type I membrane protein which contains threeSRCR domains. CD6 \/ TP120 is a cell surface glycoprotein expressed primarily on T cells, it may function as a costimulatory molecule and may play a role in autoreactive immune responses. CD6 \/ TP120 is expressed by thymocytes, mature T-cells, a subset of B-cells known as B-1 cells, and by some cells in the brain. CD6 ligand termed CD166 (previously known as activated leukocyte cell adhesion molecule, ALCAM ) has been identified and shown to be expressed on activated T cells, B cells, thymic epithelium, keratinocytes, and in rheumatoid arthritis synovial tissue. CD6 \/ TP120 binds to activated leukocyte cell adhesion molecule ( CD166 ), and is considered as a costimulatory molecule involved in lymphocyte activation and thymocyte development. CD6 \/ TP120 partially associates with the TCR \/ CD3 complex and colocalizes with it at the center of the mature immunological synapse (IS) on T lymphocytes. During thymic development CD6-dependent signals may contribute both to thymocyte survival, and to the overall functional avidity of selection in both man and mouse.\n\nActivity: Measured by the ability of the immobilized protein to support the adhesion of Jurkat human acute T cell leukemia cells. When 8 x 10\u003csup\u003e4\u003c\/sup\u003ecells\/well are added to mCD6-Fc coated plates (10μg\/mL, 100 μL\/well), approximately 14.4% will adhere after 60 minutes at 37℃.\n\nSequence: Met 1-Val 243\n\nPurity: \u0026gt; 85 % as determined by reducing SDS-PAGE.\n\nFormulation: Lyophilized from sterile PBS, pH 7.4\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\nPlease refer to the specific buffer information in the printed manual.\n\nReconstitution: Please refer to the printed manual for detailed information.\n\nEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\n\nCalculated MW: 68.2 kDa\n\nObserved MW: 80-90 kDa\n\nStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\n\nShipping: This product is provided as lyophilized powder which is shipped with ice packs.\n\nResearch Use Only","brand":"Elabscience","offers":[{"title":"Default Title","offer_id":43104359743667,"sku":"PKSM040530-100","price":635.6,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_6604fa9e-d245-4b99-9884-c8ca0b81c091.png?v=1709295194","url":"https:\/\/afsbio.com\/products\/recombinant-mouse-cd6-tp120-protein-fc-tagactive-pksm040530","provider":"AFSBio Inc.","version":"1.0","type":"link"}