{"product_id":"recombinant-mouse-col4-protein-his-tag-pdmm100035","title":"Recombinant Mouse COL4 protein (His tag) - PDMM100035","description":"\u003cp\u003eRecombinant Mouse COL4 protein (His tag)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μg, 100μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PDMM100035-20, PDMM100035-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: COL4\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: Collagen alpha-1(IV) chain; Arresten; Col4a1\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: P02463\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal Transduction; Cancer; Stem Cells; Cardiovascular\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Mouse\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: HEK293 Cells\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: C-His\u003c\/p\u003e\n\n\u003cp\u003eAccession: P02463\u003c\/p\u003e\n\n\u003cp\u003eBackground: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin\/nidogen.\u003cbr\u003e\nArresten, comprising the C-terminal NC1 domain, inhibits angiogenesis and tumor formation. The C-terminal half is found to possess the anti-angiogenic activity. Specifically inhibits endothelial cell proliferation, migration and tube formation. Inhibits expression of hypoxia-inducible factor 1alpha and ERK1\/2 and p38 MAPK activation. Ligand for alpha1\/beta1 integrin.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Ser1441-Thr1669\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from sterile PBS, pH 7.4.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: Please contact us for more information.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 25.08 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 30 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"20μg","offer_id":43083633983667,"sku":"PDMM100035-20","price":418.6,"currency_code":"CAD","in_stock":true},{"title":"100μg","offer_id":43083634016435,"sku":"PDMM100035-100","price":698.6,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_0fb3887d-e6db-4039-9114-e6d550f505a9.png?v=1708945681","url":"https:\/\/afsbio.com\/products\/recombinant-mouse-col4-protein-his-tag-pdmm100035","provider":"AFSBio Inc.","version":"1.0","type":"link"}