{"product_id":"recombinant-mouse-cripto-tdgf1-protein-rp01946","title":"Recombinant Mouse Cripto\/TDGF1 Protein - RP01946","description":"\u003cp\u003eRecombinant Mouse Cripto\/TDGF1 Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10ug, 20g, 50ug, 100ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RP01946-10, RP01946-20, RP01946-50, RP01946-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Mouse Cripto\/TDGF1 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Arg26-Gln150) of Mouse Cripto\/TDGF1(Accession #NP_035692.2) fused with a His tag at the C-terminus.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: Cripto, Tdgf1,  Teratocarcinoma-derived growth factor, Cripto growth factor, Epidermal growth factor-like Cripto protein\u003c\/p\u003e\n\n\u003cp\u003eSWISS: P51865\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 21667\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Mouse\u003c\/p\u003e\n\n\u003cp\u003ePurity: ≥ 90 % as determined by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20℃. Store the lyophilized protein at -20℃ to -80℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Cripto\/TDGF1 is a member of the epidermal growth factor (EGF)- Cripto, Frl-1, and Cryptic (CFC) family. TDGF1 is an extracellular, membrane-bound signaling protein that plays an essential role in embryonic development and tumor growth. It is overexpressed in many types of cancers and acts as a growth factor for tumors. Cripto mutants display defects in mesoderm induction and heart morphogenesis, similar to phenotypes seen in Nodal mutants. Cripto can also activate mitogen-activated protein kinase (MAPK) and Akt pathways independently of Nodal by directly binding to a membrane-associated heparan sulfate proteoglycan, glypican-1.\u003c\/p\u003e\n\n\u003cp\u003eSource: HEK293 cells\u003c\/p\u003e\n\n\u003cp\u003eTag: C-His\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.\u003c\/p\u003e\n\n\u003cp\u003eAntigen Sequence: RDLAIRDNSIWDQKEPAVRDRSFQFVPSVGIQNSKSLNKTCCLNGGTCILGSFCACPPSFYGRNCEHDVRKEHCGSILHGTWLPKKCSLCRCWHGQLHCLPQTFLPGCDGHVMDQDLKASGTPCQ\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 0.1 EU\/μg of the protein by LAL method.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"10ug","offer_id":45198267285683,"sku":"RP01946-10","price":168.0,"currency_code":"CAD","in_stock":true},{"title":"20ug","offer_id":45198267318451,"sku":"RP01946-20","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"50ug","offer_id":45198267351219,"sku":"RP01946-50","price":420.0,"currency_code":"CAD","in_stock":true},{"title":"100ug","offer_id":45198267383987,"sku":"RP01946-100","price":672.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_1953e534-2860-40a3-a162-eb3d564bc2c7.png?v=1766959915","url":"https:\/\/afsbio.com\/products\/recombinant-mouse-cripto-tdgf1-protein-rp01946","provider":"AFSBio Inc.","version":"1.0","type":"link"}