{"product_id":"recombinant-mouse-csf-1-m-csf-protein-rp01216s","title":"Recombinant Mouse CSF-1\/M-CSF Protein - RP01216S","description":"\u003cp\u003eRecombinant Mouse CSF-1\/M-CSF Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10ug, 20g, 50ug, 100ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RP01216S-10, RP01216S-20, RP01216S-50, RP01216S-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Mouse CSF-1\/M-CSF Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Met1-Pro187) of Mouse CSF-1\/M-CSF (Accession #NP_031804.3.) fused with No-tag.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: MCSF, M-CSF, CSF-1, Lanimostim, CSF1\u003c\/p\u003e\n\n\u003cp\u003eSWISS: P07141-1\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 12977\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Mouse\u003c\/p\u003e\n\n\u003cp\u003ePurity: ≥ 90% as determined by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20 ℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Macrophage colony-stimulating factor 1, also known as CSF-1, M-CSF, is a single-pass membrane protein which is disulfide-linked as a homodimer or heterodimer. Granulocyte \/ macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. M-CSF\/CSF-1 is known to facilitate monocyte survival, monocyte-to-macrophage conversion, and macrophage proliferation. M-CSF\/CSF-1 is a secreted cytokine which influences hemopoietic stem cells to differentiate into macrophages or other related cell types. It binds to the Colony stimulating factor 1 receptor. M-CSF\/CSF-1 may also be involved in development of the placenta. The active form of M-CSF\/CSF-1 is found extracellularly as a disulfide-linked homodimer, and is thought to be produced by proteolytic cleavage of membrane-bound precursors. M-CSF\/CSF-1 induces cells of the monocyte\/macrophage lineage. It\u003c\/p\u003e \n\n\u003cp\u003eBio-Activity: Measured in a cell proliferation assay using M-NFS-60 mouse myelogenous leukemia lymphoblast cells. The ED50 for this effect is 3.76-15.16 ng\/mL, corresponding to a specific activity of 6.6×10^4 ~2.65×10^5 units\/mg.\u003c\/p\u003e\n\n\u003cp\u003eSource: HEK293 cells\u003c\/p\u003e\n\n\u003cp\u003eTag: No-Tag\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.\u003c\/p\u003e\n\n\u003cp\u003eAntigen Sequence: MTARGAAGRCPSSTWLGSRLLLVCLLMSRSIAKEVSEHCSHMIGNGHLKVLQQLIDSQMETSCQIAFEFVDQEQLDDPVCYLKKAFFLVQDIIDETMRFKDNTPNANATERLQELSNNLNSCFTKDYEEQNKACVRTFHETPLQLLEKIKNFFNETKNLLEKDWNIFTKNCNNSFAKCSSRDVVTKP\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 0.01 EU\/μg of the protein by LAL method\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"10ug","offer_id":45198344159411,"sku":"RP01216S-10","price":210.0,"currency_code":"CAD","in_stock":true},{"title":"20ug","offer_id":45198344192179,"sku":"RP01216S-20","price":308.0,"currency_code":"CAD","in_stock":true},{"title":"50ug","offer_id":45198344224947,"sku":"RP01216S-50","price":490.0,"currency_code":"CAD","in_stock":true},{"title":"100ug","offer_id":45198344257715,"sku":"RP01216S-100","price":784.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_4d08d257-6702-4882-8322-2afe9f0c4f84.png?v=1766960839","url":"https:\/\/afsbio.com\/products\/recombinant-mouse-csf-1-m-csf-protein-rp01216s","provider":"AFSBio Inc.","version":"1.0","type":"link"}