{"product_id":"recombinant-mouse-ctla4-cd152-protein-his-tagactive-pksm040643","title":"Recombinant Mouse CTLA4\/CD152 Protein (His Tag)(Active) - PKSM040643","description":"\u003cp\u003eRecombinant Mouse CTLA4\/CD152 Protein (His Tag)(Active)\u003c\/p\u003e\n\n\u003cp\u003eSize: 100μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: PKSM040643-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: CTLA4; CD152\u003c\/p\u003e\n\n\u003cp\u003eTarget Symptom: Cd152; Ctla-4; Ly-56\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Mouse\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: HEK293 Cells\u003c\/p\u003e\n\n\u003cp\u003eApplication: ELISA\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: C-His\u003c\/p\u003e\n\n\u003cp\u003eAccession: NP_033973.2\u003c\/p\u003e\n\n\u003cp\u003eBackground: Cytotoxic T-lymphocyte protein 4, also known as CTLA4 and CD152, is a single-pass type I membrane protein and a member of the immunoglobulin superfamily. It is the second member of the CD28 receptor family. The ligands or counterreceptors for these two proteins are the B7 family members, CD80 (B7-1) and CD86 (B7-2). CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may play an important role in their functions. CD152 or cytotoxic T lymphocyte antigen-4 (CTLA-4) is an essential receptor involved in the negative regulation of T cell activation. Because of its profound inhibitory role, CD152 has been considered a sound susceptible candidate in autoimmunity and a persuasive target for cancer immunotherapy. In particular, recent evidence suggests that CD152 is also important in the homeostasis and function of a population of suppressive cells, termed regulatory T cells (Treg).\u003c\/p\u003e\n\n\u003cp\u003eActivity: 1. Immobilized recombinant mouse CTLA4-His at 10 μg\/ml (100 μl\/well) can mouse CD80-Fc with a linear range of 0.78-62. 5 ng\/ml. \u003cbr\u003e\n2. Immobilized recombinant mouse CTLA4-His at 10 μg\/ml (100 μl\/well) can human B7-1-Fc with a linear range of 0.78-125 ng\/ml.\u003c\/p\u003e \n\n\u003cp\u003eSequence: Met 1-Phe 162\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 98 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from sterile PBS, pH 7.4\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 15.3 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 25-30 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"Default Title","offer_id":43104266289331,"sku":"PKSM040643-100","price":473.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_2c7134dd-17bf-4e04-ab3b-9fb2979298d9.png?v=1709293399","url":"https:\/\/afsbio.com\/products\/recombinant-mouse-ctla4-cd152-protein-his-tagactive-pksm040643","provider":"AFSBio Inc.","version":"1.0","type":"link"}