{"product_id":"recombinant-mouse-cx3cl1-fractalkine-protein-his-tag-pksm040991","title":"Recombinant Mouse CX3CL1\/Fractalkine Protein (His Tag) - PKSM040991","description":"\u003cp\u003eRecombinant Mouse CX3CL1\/Fractalkine Protein (His Tag)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10μg, 50μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSM040991-10, PKSM040991-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: CX3CL1; Fractalkine\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: Fractalkine; C-X3-C motif chemokine 1; CX3C membrane-anchored chemokine; Neurotactin; Small-inducible cytokine D1; Cx3c; Fkn; Scyd1; CXC3; CXC3C; ABCD-3; SCYD1; C3Xkine; NTN; NTT\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: O35188\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Mouse\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: HEK293 Cells\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: C-6His\u003c\/p\u003e\n\n\u003cp\u003eAccession: O35188\u003c\/p\u003e\n\n\u003cp\u003eBackground: Fractalkine(CX3CL1) is a single-pass type I membrane protein and belongs to the intercrine delta family. It consists of an extracellular NH2-terminal domain, a mucin-like stalk, a transmembrane α helix, and a short cytoplasmic tail. CX3CL1 exists in two forms: as a membrane-anchored or as a shed 80-95K glycoprotein. Soluble CX3CL1 is generated by limited proteolysis on the cell surface, and a disintegrin and metallopeptidase 10 (ADAM10) and ADAM17\/tumor necrosis factor-α-converting enzyme (ADAM17\/TACE) participate in this shedding. It has been suggested that ADAM10 acts in the constitutive shedding, and ADAM17 acts in response to cell activation. The protein may play a role in regulating leukocyte adhesion and migration processes at the endothelium.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Gln25-Arg337\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH7.4.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 34.3 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 58-60 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"10μg","offer_id":43149132071091,"sku":"PKSM040991-10","price":163.8,"currency_code":"CAD","in_stock":true},{"title":"50μg","offer_id":43149132103859,"sku":"PKSM040991-50","price":415.8,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_0c659f54-007a-43e8-9ca8-481c0ef7e31d.png?v=1710341230","url":"https:\/\/afsbio.com\/products\/recombinant-mouse-cx3cl1-fractalkine-protein-his-tag-pksm040991","provider":"AFSBio Inc.","version":"1.0","type":"link"}