{"product_id":"recombinant-mouse-cxcl2-mip-2-protein-rp01882","title":"Recombinant Mouse CXCL2\/MIP-2 Protein - RP01882","description":"\u003cp\u003eRecombinant Mouse CXCL2\/MIP-2 Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10ug, 20g, 50ug, 100ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RP01882-10, RP01882-20, RP01882-50, RP01882-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Mouse CXCL2\/MIP-2 Protein is produced by Pichia expression system. The target protein is expressed with sequence (Ala28-Asn100) of Mouse CXCL2\/MIP-2 (Accession #NP_033166.1) fused with a His tag at the C-terminus.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: Cxcl2, Mip-2, Mip2, Scyb2, C-X-C motif chemokine 2, Macrophage inflammatory protein 2, MIP2\u003c\/p\u003e\n\n\u003cp\u003eSWISS: P10889\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 20310\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Mouse\u003c\/p\u003e\n\n\u003cp\u003ePurity: ≥ 95 % as determined by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20 ℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Macrophage Inflammatory Protein-2 (MIP-2) was originally identified as a heparin-binding protein secreted from a murine macrophage cell line in response to endotoxin stimulation. Based on its protein and DNA sequences, MIP-2 is a member of the alpha (C-X-C) subfamily of chemokines.MIP-2 cDNA encodes a 100 amino acid residue precursor protein from which the amino-terminal 27 amino acid residues are cleaved to generate the mature MIP-2. The protein sequence of murine MIP-2 shows approximately 63% identity to that of murine KC, another murine alpha chemokine whose expression is induced by PDGF. In addition, the protein sequence of MIP-2 is also 60% identical to human GRO beta and GRO gamma. It has been suggested that mouse KC and MIP-2 are the homologs of the human GROs and rat CINCs.Similarly to other alpha chemokines, murine MIP-2 is a potent neutrophil attractant and activator. MIP-2 and KC can bind the murine interleukin 8 type B receptor homologue with high affinity. The expression of MIP-2 was found to be associated with neutrophil influx in pulmonary inflammation and glomerulonephritis, suggesting that MIP-2 may contribute to the pathogenesis of inflammatory diseases.\u003c\/p\u003e\n\n\u003cp\u003eSource: Pichia\u003c\/p\u003e\n\n\u003cp\u003eTag: C-6His\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.\u003c\/p\u003e\n\n\u003cp\u003eAntigen Sequence: VVASELRCQCLKTLPRVDFKNIQSLSVTPPGPHCAQTEVIATLKGGQKVCLDPEAPLVQKIIQKILNKGKAN\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 0.1 EU\/μg of the protein by LAL method.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"10ug","offer_id":45198269382835,"sku":"RP01882-10","price":210.0,"currency_code":"CAD","in_stock":true},{"title":"20ug","offer_id":45198269415603,"sku":"RP01882-20","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"50ug","offer_id":45198269448371,"sku":"RP01882-50","price":350.0,"currency_code":"CAD","in_stock":true},{"title":"100ug","offer_id":45198269481139,"sku":"RP01882-100","price":560.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_dec3dd0e-c9d9-4da9-b074-970256c10557.png?v=1766959938","url":"https:\/\/afsbio.com\/products\/recombinant-mouse-cxcl2-mip-2-protein-rp01882","provider":"AFSBio Inc.","version":"1.0","type":"link"}