{"product_id":"recombinant-mouse-cxcl7-40-113-proteinn-hisactive-pksm041515","title":"Recombinant Mouse CXCL7 (40-113) protein(N-His)(active) - PKSM041515","description":"\u003cp\u003eRecombinant Mouse CXCL7 (40-113) protein(N-His)(active)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μg, 100μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSM041515-20, PKSM041515-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: CXCL7\u003c\/p\u003e\n\n\u003cp\u003eTarget Symptom: MIP-1b: Macrophage Inflammatory Protein-1β; ACT-2\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Mouse\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: E.coli\u003c\/p\u003e\n\n\u003cp\u003eApplication: Cell culture\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: N-His\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: Q9EQI5\u003c\/p\u003e\n\n\u003cp\u003eAccession: Q9EQI5\u003c\/p\u003e\n\n\u003cp\u003eBackground: Human Chemokine (C-X-C motif) Ligand 7 (CXCL7); also known as neutrophil activating peptide 2 (NAP-2); is a member of the CXC chemokines containing an ELR domain (Glu-Leu-Arg tripeptide motif). Similar to other ELR domain containing CXC chemokines; such as IL-8 and the GRO proteins; CXCL7 binds CXCR2; chemoattracts and activates neutrophils. CXCL7; Connective Tissue Activating Protein III (CTAPIII) and βthrombogulin (βTG); are proteolytically processed carboxylterminal fragments of platelet basic protein (PBP) which is found in the alphagranules of human platelets. Although CTAPIII; βTG; and PBP represent amino-terminal extended variants of NAP2 and possess the same CXC chemokine domains; these proteins do not exhibit CXCL7\/NAP2 activity. CXCL7 induces cell migration through the G-protein-linked receptor CXCR-2.\u003c\/p\u003e\n\n\u003cp\u003eActivity: Measure by its ability to chemoattract BaF3 cells transfected with human CXCR2. The ED50 for this effect is \u0026lt; 1 μg\/mL.\u003c\/p\u003e\n\n\u003cp\u003eSequence: MGFRLRPTSSCTRACPLHNLQILLLLGLILVALAPLTAGKSDGMDPYIELRCRCTNTISGIPFNSISLVNVYRPGVHCADVEVIATLKNGQKTCLDPNAPGVKRIVMKILEGY\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 98 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from sterile PBS, pH 7.4\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 0.1 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 13.08 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"20μg","offer_id":43118185152691,"sku":"PKSM041515-20","price":348.6,"currency_code":"CAD","in_stock":true},{"title":"100μg","offer_id":43118185185459,"sku":"PKSM041515-100","price":1034.6,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_deb59436-6664-4035-af25-1dd7092e2701.png?v=1709637724","url":"https:\/\/afsbio.com\/products\/recombinant-mouse-cxcl7-40-113-proteinn-hisactive-pksm041515","provider":"AFSBio Inc.","version":"1.0","type":"link"}