{"product_id":"recombinant-mouse-icam-2-cd102-protein-active-pksm040565","title":"Recombinant Mouse ICAM-2\/CD102 Protein (Active) - PKSM040565","description":"Recombinant Mouse ICAM-2\/CD102 Protein (Active)\n\nSize: 100μg\n\nCatalogue Number: PKSM040565-100\n\nCitations, Manuals and MSDS Available upon request.\n\nAbbreviation: ICAM-2; CD102\n\nTarget Symptom: AILIM Protein; CCLP Protein; CRP-1 Protein; H4 Protein; Ly115 Protein\n\nTarget Species: Mouse\n\nExpression Host: HEK293 Cells\n\nApplication: Cell culture; ELISA\n\nFusion Tag: None\n\nAccession: NP_034624.1\n\nBackground: Intercellular adhesion molecule 2 (ICAM-2, CD102), belongs to the ICAM family consisting of three members identified as ligands for integrin receptors. It is a type I transmembrane glycoprotein with two Ig-like C2-type domains, and binds to the leukocyte integrins LFA-1 (CD11a\/CD18) and Mac-1 (CD11b\/CD18). As a second ligand of leukocyte function-associated antigen-1, ICAM-2 functions as a costimulatory molecule for effector cells. ICAM-2 is mainly expressed on vascular endothelial and hematopoietic cells. Interactions of ICAM-2 and the integrin receptors mediate cell adhesion in a wide range of lymphocyte, monocyte, natural killer cell, and granulocytewith other cells, and play important roles in many adhesion-dependent immune and inflammation responses, such as T cell aggregation, NK-cell cytotoxicity and migration, lymphocyte recirculation, etc. Serum levels of ICAM-2 correlated significantly with the inflammatory and course sequences of trichinosis in mice and had a similar relation with blood eosinophilia. So, estimation of ICAM-2 serum levels may prove useful in diagnosis of trichinosis recent infections, and in monitoring the prognosis and response to treatment.\n\nActivity: Measured by the ability of the immobilized protein to support the adhesion of PMA-stimulated HSB2 human peripheral blood acute lymphoblastic leukemia cells. When 5 x 10\u003csup\u003e4\u003c\/sup\u003e cells\/well are added to rmICAM1 coated plates (12.5 μg\/mL with 100 μL\/well), \u0026gt; 30% cells will adhere after 1 hour incubation at 37℃.\n\nSequence: Met 1-Gln 222\n\nPurity: \u0026gt; 85 % as determined by reducing SDS-PAGE.\n\nFormulation: Lyophilized from sterile PBS, pH 7.4 \nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\nPlease refer to the specific buffer information in the printed manual.\n\nReconstitution: Please refer to the printed manual for detailed information.\n\nEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\n\nCalculated MW: 23.6 kDa\n\nObserved MW: 38-42 kDa\n\nStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\n\nShipping: This product is provided as lyophilized powder which is shipped with ice packs.\n\nResearch Use Only","brand":"Elabscience","offers":[{"title":"Default Title","offer_id":43104262258867,"sku":"PKSM040565-100","price":1316.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_a55e89f3-5de4-4003-ad24-af292c2df996.png?v=1709293316","url":"https:\/\/afsbio.com\/products\/recombinant-mouse-icam-2-cd102-protein-active-pksm040565","provider":"AFSBio Inc.","version":"1.0","type":"link"}