{"product_id":"recombinant-mouse-igf-i-protein-rp01887","title":"Recombinant Mouse IGF-I Protein - RP01887","description":"\u003cp\u003eRecombinant Mouse IGF-I Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10ug, 20g, 50ug, 100ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RP01887-10, RP01887-20, RP01887-50, RP01887-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Mouse IGF-I Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gly49-Ala118) of Mouse IGF-I (Accession #NP_001104745.1) fused with a hFc tag at the N-terminus.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: Igf1, Igf-1, Insulin-like growth factor I, IGF-I, Somatomedin\u003c\/p\u003e\n\n\u003cp\u003eSWISS: P05017\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 16000\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Mouse\u003c\/p\u003e\n\n\u003cp\u003ePurity: ≥ 95 % as determined by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20 ℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Insulin-like growth factor I, also known as somatomedin C, is the dominant effector of growth hormone and is structurally homologous to proinsulin. Mouse IGF-I\/IGF-1 is synthesized as two precursor isoforms with alternate N- and C-terminal propeptides. These isoforms are differentially expressed by various tissues. The 7.6 kDa mature IGF-I\/IGF-1 is identical between isoforms and is generated by proteolytic removal of the N- and C-terminal regions. Mature mouse IGF-I\/IGF-1 shares 94% and 99% aa sequence identity with human and rat IGF-I\/IGF-1, respectively, and exhibits cross-species activity. It shares 60% aa sequence identity with mature mouse IGF-II\/IGF-2. Circulating IGF-I\/IGF-1 is produced by hepatocytes, while local IGF-I is produced by many other tissues in which it has paracrine effects. IGF-I induces the proliferation, migration, and differentiation of a wide variety of cell types during development and postnatally. IGF-I regulates glucose and fatty acid metabolism, steroid hormone activity, and cartilage and bone metabolism. It plays an important role in muscle regeneration and tumor progression. IGF-I binds IGF-I R, IGF-II R, and the insulin receptor, although its effects are mediated primarily by IGF-I R. IGF-I association with IGF binding proteins increases its plasma half-life and modulates its interactions with receptors.\u003c\/p\u003e\n\n\u003cp\u003eSource: HEK293 cells\u003c\/p\u003e\n\n\u003cp\u003eTag: N-hFc\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.\u003c\/p\u003e\n\n\u003cp\u003eAntigen Sequence: GPETLCGAELVDALQFVCGPRGFYFNKPTGYGSSIRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPTKAA\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 0.01 EU\/μg of the protein by LAL method\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"10ug","offer_id":45198254538931,"sku":"RP01887-10","price":182.0,"currency_code":"CAD","in_stock":true},{"title":"20ug","offer_id":45198254571699,"sku":"RP01887-20","price":217.0,"currency_code":"CAD","in_stock":true},{"title":"50ug","offer_id":45198254604467,"sku":"RP01887-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100ug","offer_id":45198254637235,"sku":"RP01887-100","price":420.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_6a3e5a66-83cb-4fb3-93c6-d4437ca2086d.png?v=1766959778","url":"https:\/\/afsbio.com\/products\/recombinant-mouse-igf-i-protein-rp01887","provider":"AFSBio Inc.","version":"1.0","type":"link"}