{"product_id":"recombinant-mouse-igf1-igf-i-igf-1-protein-his-tag-pdem100099","title":"Recombinant mouse IGF1\/IGF‑I\/IGF-1 protein (His tag) - PDEM100099","description":"\u003cp\u003eRecombinant mouse IGF1\/IGF‑I\/IGF-1 protein (His tag)\u003c\/p\u003e\n\n\u003cp\u003eSize: 100μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PDEM100099-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: IGF1; IGF-1\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: IGF1; IGF-1; insulin-like growth factor 1; Insulin-like growth factor I; Somatomedin C; somatomedin-C\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: P05017\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer; Developmental Biology; Neuroscience; Signal Transduction; Stem Cells; Metabolism\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: mouse\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: E.coli\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: N-His\u003c\/p\u003e\n\n\u003cp\u003eAccession: P05017\u003c\/p\u003e\n\n\u003cp\u003eBackground: nsulin-like growth factor I (IGF1) belongs to the family of insulin-like growth factors that are structurally homologous to proinsulin. Mouse IGF-I is synthesized as two precursor isoforms with alternate N- and C-terminal propeptides. These isoforms are differentially expressed by various tissues. Mature mouse IGF-I shares 94% and 99% aa sequence identity with human and rat IGF-I, respectively, and exhibits cross-species activity. It shares 60% aa sequence identity with mature mouse IGF-II. IGF-I induces the proliferation, migration, and differentiation of a wide variety of cell types during development and postnatally. It plays an important role in muscle regeneration and tumor progression. IGF-I binds IGF-I R, IGF-II R, and the insulin receptor. IGF-I association with IGF binding proteins increases its plasma half-life and modulates its interactions with receptors.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Ala 48-Met 153\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from sterile PBS, pH 7.4.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: Please contact us for more information.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 11.55 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 14 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"100μg","offer_id":43083596366003,"sku":"PDEM100099-100","price":165.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_ed4300d2-7038-4896-901e-fd45a43b8f8d.png?v=1708944936","url":"https:\/\/afsbio.com\/products\/recombinant-mouse-igf1-igf-i-igf-1-protein-his-tag-pdem100099","provider":"AFSBio Inc.","version":"1.0","type":"link"}