{"product_id":"recombinant-mouse-igg3-fc-protein-pksm041328","title":"Recombinant Mouse IgG3-Fc Protein - PKSM041328","description":"Recombinant Mouse IgG3-Fc Protein\n\nSize: 50μg\n\nCatalogue Numbers: PKSM041328-50\n\nCitations, Manuals and MSDS Available upon request.\n\nAbbreviation: IgG3-Fc\n\nTarget Synonym: Ig gamma-3 chain C region; IgG3 Fc\n\nUNIProt ID: P03987\n\nTarget Species: Mouse\n\nExpression Host: HEK293 Cells\n\nFusion Tag: None\n\nAccession: P03987-2\n\nBackground: As a monomeric immunoglobulin that is predominately involved in the secondary antibody response and the only isotype that can pass through the human placenta, Immunoglobulin G (IgG) is synthesized and secreted by plasma B cells, and constitutes 75% of serum immunoglobulins in humans. IgG antibodies protect the body against the pathogens by agglutination and immobilization, complement activation, toxin neutralization, as well as the antibody-dependent cell-mediated cytotoxicity (ADCC). IgG tetramer contains two heavy chains (50 kDa ) and two light chains (25 kDa) linked by disulfide bonds, that is the two identical halves form the Y-like shape. IgG is digested by pepsin proteolysis into Fab fragment (antigen-binding fragment) and Fc fragment (\" crystallizable\" fragment). IgG1 is most abundant in serum among the four IgG subclasses (IgG1, 2, 3 and 4) and binds to Fc receptors (FcγR ) on phagocytic cells with high affinity. Fc fragment is demonstrated to mediate phagocytosis, trigger inflammation, and target Ig to particular tissues. Protein G or Protein A on the surface of certain Staphylococcal and Streptococcal strains specifically binds with the Fc region of IgGs, and has numerous applications in biotechnology as a reagent for affinity purification. Recombinant IgG Fc Region is suggested to represent a potential anti-inflammatory drug for treatment of human autoimmune diseases.\n\nSequence: Glu97-Lys329\n\nPurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\n\nFormulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\nPlease refer to the specific buffer information in the printed manual.\n\nReconstitution: Please refer to the printed manual for detailed information.\n\nEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\n\nCalculated MW: 26.2 kDa\n\nObserved MW: 31 kDa\n\nStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\n\nShipping: This product is provided as lyophilized powder which is shipped with ice packs.\n\nResearch Use Only","brand":"Elabscience","offers":[{"title":"50μg","offer_id":43072214401203,"sku":"PKSM041328-50","price":155.4,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_9b03b7db-7dee-4b82-a221-a54a239d59f6.png?v=1708684250","url":"https:\/\/afsbio.com\/products\/recombinant-mouse-igg3-fc-protein-pksm041328","provider":"AFSBio Inc.","version":"1.0","type":"link"}