{"product_id":"recombinant-mouse-il-15-protein-rp01676","title":"Recombinant Mouse IL-15 Protein - RP01676","description":"\u003cp\u003eRecombinant Mouse IL-15 Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20ug, 50ug, 100ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RP01676-20, RP01676-50, RP01676-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Mouse IL-15 Protein is produced by E. coli expression system. The target protein is expressed with sequence (Asn49-Ser162) of mouse IL-15 (Accession #NP_001241676.1) fused with and a 6×His tag at the C-terminus.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: Il15, Interleukin-15, IL-15\u003c\/p\u003e\n\n\u003cp\u003eSWISS: P48346\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 16168\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Mouse\u003c\/p\u003e\n\n\u003cp\u003ePurity: ≥ 95 % as determined by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Interleukin 15 (IL-15 ) is a cytokine that regulates T and natural killer cell activation and proliferation. IL-15 induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. In mouse, studies suggest that IL-15 may increase the expression of apoptosis inhibitor Bcl-xL, possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. IL-15 plays an important role in the growth and differentiation of T and B lymphocytes, natural killer cells, macrophages, and monocytes as well as activation of a number of important intracellular signaling molecules.\u003c\/p\u003e \n\n\u003cp\u003eBio-Activity: 1.Measured in a cell proliferation assay using HT-2 mouse T cells. The ED50 for this effect is 15-58 ng\/mL, corresponding to a specific activity of 1.72×10^4 -6.67×10^4 units\/mg.2.Measured in a cell proliferation assay using CTLL‑2 mouse T cells. The ED50 for this effect is 8.1‑32.4ng\/mL,corresponding to a specific activity of 3.09×104~1.23×105units\/mg.\u003c\/p\u003e\n\n\u003cp\u003eSource: E. coli\u003c\/p\u003e\n\n\u003cp\u003eTag: C-6His\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.\u003c\/p\u003e\n\n\u003cp\u003eAntigen Sequence: NWIDVRYDLEKIESLIQSIHIDTTLYTDSDFHPSCKVTAMNCFLLELQVILHEYSNMTLNETVRNVLYLANSTLSSNKNVAESGCKECEELEEKTFTEFLQSFIRIVQMFINTS\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1 EU\/μg of the protein by LAL method.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"20ug","offer_id":45198384988339,"sku":"RP01676-20","price":308.0,"currency_code":"CAD","in_stock":true},{"title":"50ug","offer_id":45198385021107,"sku":"RP01676-50","price":490.0,"currency_code":"CAD","in_stock":true},{"title":"100ug","offer_id":45198385053875,"sku":"RP01676-100","price":784.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_2f79dc9f-fa6c-416e-9fd4-3a849d3081fd.png?v=1766961529","url":"https:\/\/afsbio.com\/products\/recombinant-mouse-il-15-protein-rp01676","provider":"AFSBio Inc.","version":"1.0","type":"link"}