{"product_id":"recombinant-mouse-il-1ra-il-1f3-il-1rn-protein-rp00666","title":"Recombinant Mouse IL-1Ra\/IL-1F3\/IL-1RN Protein - RP00666","description":"\u003cp\u003eRecombinant Mouse IL-1Ra\/IL-1F3\/IL-1RN Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10ug, 20g, 50ug, 100ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RP00666-10, RP00666-20, RP00666-50, RP00666-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Mouse IL-1Ra\/IL-1F3\/IL-1RN Protein is produced by E. coli expression system. The target protein is expressed with sequence (Arg27-Gln178) of mouse IL-1Ra\/IL-1F3\/IL-1RN (Accession #P25085) fused with an initial Met at the N-terminus.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: IL-1ra, F630041P17Rik, IL1RN\u003c\/p\u003e\n\n\u003cp\u003eSWISS: P25085\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 16181\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Mouse\u003c\/p\u003e\n\n\u003cp\u003ePurity: ≥ 95 % as determined by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20 ℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Interleukin-1 receptor antagonist protein (Il1rn), also known as IL-1ra, IRAP or IL1 inhibitor, is a member of theinterleukin 1 cytokine family. This protein inhibits the activities of interleukin 1 alpha (IL1A) and interleukin 1beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. The mouseIl1rn gene encodes a 178 amino acids (aa) protein with a 26 aa signal peptide. Mouse Il1rn protein shares 26%and 19% identity with its homologues IL-1 beta and IL-1 alpha, respectively. Il1rn can Inhibits the activity ofinterleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP forsignaling, but has no interleukin-1 like activity. Recently, an recombinant human Il1rn protein is used in thetreatment of rheumatoid arthritis, an autoimmune disease in which IL-1 plays a key role.\u003c\/p\u003e\n\n\u003cp\u003eBio-Activity: Measured by its ability to inhibit IL-1 alpha-dependent proliferation in D10.G4.1 mouse helper T cells. The ED50 for this effect is 2.47-9.86 ng\/mL in the presence of 3ng\/mL of recombinant human IL-1 alpha(Catalog: RP00098), corresponding to a specific activity of 1.01×10^5 ~4.05×10^5 units\/mg.\u003c\/p\u003e\n\n\u003cp\u003eSource: E. coli\u003c\/p\u003e\n\n\u003cp\u003eTag: No tag\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.\u003c\/p\u003e\n\n\u003cp\u003eAntigen Sequence: RPSGKRPCKMQAFRIWDTNQKTFYLRNNQLIAGYLQGPNIKLEEKIDMVPIDLHSVFLGIHGGKLCLSCAKSGDDIKLQLEEVNITDLSKNKEEDKRFTFIRSEKGPTTSFESAACPGWFLCTTLEADRPVSLTNTPEEPLIVTKFYFQEDQ\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1 EU\/μg of the protein by LAL method.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"10ug","offer_id":45198307295411,"sku":"RP00666-10","price":210.0,"currency_code":"CAD","in_stock":true},{"title":"20ug","offer_id":45198307328179,"sku":"RP00666-20","price":308.0,"currency_code":"CAD","in_stock":true},{"title":"50ug","offer_id":45198307360947,"sku":"RP00666-50","price":490.0,"currency_code":"CAD","in_stock":true},{"title":"100ug","offer_id":45198307393715,"sku":"RP00666-100","price":784.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_6af5e380-d5f0-490e-82d8-c592213ba805.png?v=1766960415","url":"https:\/\/afsbio.com\/products\/recombinant-mouse-il-1ra-il-1f3-il-1rn-protein-rp00666","provider":"AFSBio Inc.","version":"1.0","type":"link"}