{"product_id":"recombinant-mouse-il-1ra-il-1f3-protein-his-tag-pdem100047","title":"Recombinant Mouse IL-1ra\/IL-1F3 protein (His tag) - PDEM100047","description":"\u003cp\u003eRecombinant Mouse IL-1ra\/IL-1F3 protein (His tag)\u003c\/p\u003e\n\n\u003cp\u003eSize: 100μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PDEM100047-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: IL-1ra; IL-1F3\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: IL-1RN; IL-1ra; IRAP; IL1 inhibitor; Il1rn; Interleukin-1 Receptor Antagonist Protein\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: P25085\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal Transduction; immunology;\u003c\/p\u003e \n\n\u003cp\u003eTarget Species: Mouse\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: E.coli\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: N-His\u003c\/p\u003e\n\n\u003cp\u003eAccession: P25085\u003c\/p\u003e\n\n\u003cp\u003eBackground: Interleukin-1 receptor antagonist protein (Il1rn), also known as IL-1ra, IRAP or IL1 inhibitor, is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1 alpha (IL1A) and interleukin 1 beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. The mouse Il1rn gene encodes a 178 amino acids (aa) protein with a 26 aa signal peptide. Mouse Il1rn protein shares 26% and 19% identity with its homologues IL-1 beta and IL-1 alpha, respectively. Il1rn can Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling, but has no interleukin-1 like activity. Recently, an recombinant human Il1rn protein is used in the treatment of rheumatoid arthritis, an autoimmune disease in which IL-1 plays a key role.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Arg 27-Gln 178\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from sterile PBS, pH 7.4.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: Please contact us for more information.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 16.61 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 18 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"100μg","offer_id":43083570806963,"sku":"PDEM100047-100","price":165.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_b707b8b1-72b6-45d5-aaf0-c48d1ac6003c.png?v=1708944809","url":"https:\/\/afsbio.com\/products\/recombinant-mouse-il-1ra-il-1f3-protein-his-tag-pdem100047","provider":"AFSBio Inc.","version":"1.0","type":"link"}