{"product_id":"recombinant-mouse-il-21-proteinn-hisactive-pksm041469","title":"Recombinant Mouse IL-21 protein(N-His)(active) - PKSM041469","description":"Recombinant Mouse IL-21 protein(N-His)(active)\n\nSizes: 20μg, 100μg\n\nCatalogue Numbers: PKSM041469-20, PKSM041469-100\n\nCitations, Manuals and MSDS Available upon request.\n\nAbbreviation: IL-21\n\nTarget Symptom: Interleukin-21; Za11; IL21; \n\nTarget Species: Mouse\n\nExpression Host: E.coli\n\nApplication: Cell culture\n\nFusion Tag: N-His\n\nUNIProt ID: Q9ES17\n\nAccession: Q9ES17\n\nBackground: IL-21 is a potent cytokine regulating many cell types of the immune system. IL-21 is produced by activated T follicular helper cells (Tfh), Th17 cells, and NKT cells. Tfh-derived IL-21 plays an important role in the development of humoral immunity through its autocrine effects on the Tfh cell and paracrine effects on immunoglobulin affinity maturation, plasma cell differentiation, and B cell memory responses. IL-21 protein regulates several aspects of T cell function. It co-stimulates the activation, proliferation, and survival of CD8+ T cells and NKT cells and promotes Th17 cell polarization. IL-21 blocks the generation of regulatory T cells and their suppressive effects on CD4+ T cells. In addition to its role in T cell biology, IL-21 also plays a critical role in B cell activation, proliferation, differentiation, and apoptosis. It is also required for the migration of dendritic cells to draining lymph nodes. And IL-21 suppresses cutaneous hypersensitivity reactions by limiting allergen-specific IgE production and mast cell degranulation. In the autoimmune disease Systemic lupus erythematosus (SLE), a link between IL-21 and SLE disease susceptibility and progression was recently reported.\n\nActivity: Measure by its ability to enhance IFN gamma secretion in NK-92 cells. The ED50 for this effect is \u0026lt; 6 ng\/mL. The specific activity of recombinant mouse IL-21 is \u0026gt; 1. 6 x 10\u003csup\u003e5\u003c\/sup\u003eIU\/mg.\n\nSequence: MERTLVCLVVIFLGTVAHKSSPQGPDRLLIRLRHLIDIVEQLKIYENDLDPELLSAPQDVKGHCEHAAFACFQKAKLKPSNPGNNKTFIIDLVAQLRRRLPARRGGKKQKHIAKCPSCDSYEKRTPKEFLERLKWLLQKMIHQHLS\n\nPurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\n\nFormulation: Lyophilized from sterile PBS, pH 7.4\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\nPlease refer to the specific buffer information in the printed manual.\n\nReconstitution: Please refer to the printed manual for detailed information.\n\nEndotoxin: \u0026lt; 0.1 EU per μg of the protein as determined by the LAL method.\n\nCalculated MW: 17.64 kDa\n\nStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\n\nShipping: This product is provided as lyophilized powder which is shipped with ice packs.\n\nResearch Use Only","brand":"Elabscience","offers":[{"title":"20μg","offer_id":43118178074803,"sku":"PKSM041469-20","price":348.6,"currency_code":"CAD","in_stock":true},{"title":"100μg","offer_id":43118178107571,"sku":"PKSM041469-100","price":1034.6,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_41e60a81-ce96-4919-b0a9-86605d09fa46.png?v=1709637586","url":"https:\/\/afsbio.com\/products\/recombinant-mouse-il-21-proteinn-hisactive-pksm041469","provider":"AFSBio Inc.","version":"1.0","type":"link"}