{"product_id":"recombinant-mouse-il-23r-protein-rp00689","title":"Recombinant Mouse IL-23R Protein - RP00689","description":"\u003cp\u003eRecombinant Mouse IL-23R Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10ug, 50ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: RP00689-10, RP00689-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Mouse IL-23R\/IL-23 Receptor Protein is produced by Human Cells expression system. The target protein is expressed with sequence (Gly24-Asp372) of mouse IL-23R\/IL-23 Receptor (Accession #Q8K4B4) fused with an Fc tag at the C-terminus.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: Interleukin-23 receptor, Il23r, IL-23 receptor, IL-23R, interleukin 23 receptor\u003c\/p\u003e\n\n\u003cp\u003eSWISS: Q8K4B4\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 209590\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Mouse\u003c\/p\u003e\n\n\u003cp\u003ePurity: ≥ 95 % as determined by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Interleukin 23 receptor (IL23R), a heterodimer of the IL12 receptor β 1 (IL12R β 1) and IL12R β 2, is a type Icytokine receptor for IL23. IL23R is comprised of two subunits, the IL12R β 1 subunit, which is shared withseveral cytokines, and a subunit that is unique to IL-23. IL23, after binding to IL23R, activates memory T cellsand mediates pro-inflammatory activities in part by the production of IL17 through activation of TH17lymphocytes. IL23R is expressed on T cells, NK cells, dendritic cells, and macrophages. In fact, polymorphismsof the IL23R gene were reported to be associated with susceptibility to inflammatory diseases andautoimmune diseases such as psoriasis, multiple sclerosis, Graves's ophtalmopathy and inflammatory boweldiseases. The IL23R is known to be critically involved in the carcinogenesis of different malignant tumor.\u003c\/p\u003e\n\n\u003cp\u003eSource: HEK293 cells\u003c\/p\u003e\n\n\u003cp\u003eTag: C-Fc\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.2 μM filtered solution of PBS, pH 7.4Contact us for customized product form or formulation.\u003c\/p\u003e\n\n\u003cp\u003eAntigen Sequence: GITSINCSGDMWVEPGEIFQMGMNVSIYCQEALKHCRPRNLYFYKNGFKEEFDITRINRTTARIWYKGFSEPHAYMHCTAECPGHFQETLICGKDISSGHPPDAPSNLTCVIYEYSGNMTCTWNTGKPTYIDTKYIVHVKSLETEEEQQYLASSYVKISTDSLQGSRKYLVWVQAVNSLGMENSQQLHVHLDDIVIPSASIISRAETTNDTVPKTIVYWKSKTMIEKVFCEMRYKTTTNQTWSVKEFDANFTYVQQSEFYLEPDSKYVFQVRCQETGKRNWQPWSSPFVHQTSQETGKRNWQPWSSPFVHQTSQTVSQVTAKSSHEPQKMEMLSATIFRGHPASGNHQD\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1 EU\/μg of the protein by LAL method.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"10ug","offer_id":45198352810163,"sku":"RP00689-10","price":210.0,"currency_code":"CAD","in_stock":true},{"title":"50ug","offer_id":45198352842931,"sku":"RP00689-50","price":420.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_48214321-9b64-419c-a8b3-60709fbaffd5.png?v=1766960974","url":"https:\/\/afsbio.com\/products\/recombinant-mouse-il-23r-protein-rp00689","provider":"AFSBio Inc.","version":"1.0","type":"link"}