{"product_id":"recombinant-mouse-il-31-protein-rp01835","title":"Recombinant Mouse IL-31 Protein - RP01835","description":"\u003cp\u003eRecombinant Mouse IL-31 Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10ug, 20g, 50ug, 100ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RP01835-10, RP01835-20, RP01835-50, RP01835-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Mouse IL-31 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Thr24-Cys163) of mouse IL-31 (Accession #NP_083870.1) fused with a 6×His tag at the C-terminus.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: 1700013B14Rik; IL-31; il31; IL31; Il-31; interleukin 31\u003c\/p\u003e\n\n\u003cp\u003eSWISS: Q6EAL8\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 76399\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Mouse\u003c\/p\u003e\n\n\u003cp\u003ePurity: ≥ 90 % as determined by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20 ℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\n\u003cp\u003eBackground: IL-31 is an inflammatory cytokine that helps trigger cell-mediated immunity against pathogens. Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR. It has also been identified as a major player in a number of chronic inflammatory diseases, including atopic dermatitis. May function in skin immunity. IL-31 is produced by a variety of cells, namely type 2 helper (TH2) T-cells. IL-31 sends signals through a receptor complex made of IL-31RA and oncostatin M receptor β (OSMRβ) expressed in immune and epithelial cells. These signals activate three pathways: ERK1\/2 MAP kinase, PI3K\/AKT, and JAK1\/2 signaling pathways.\u003c\/p\u003e\n\n\u003cp\u003eSource: HEK293 cells\u003c\/p\u003e\n\n\u003cp\u003eTag: C-His\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.\u003c\/p\u003e\n\n\u003cp\u003eAntigen Sequence: TCSLSFGAPISKEDLRTTIDLLKQESQDLYNNYSIKQASGMSADESIQLPCFSLDREALTNISVIIAHLEKVKVLSENTVDTSWVIRWLTNISCFNPLNLNISVPGNTDESYDCKVFVLTVLKQFSNCMAELQAKDNTTC\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 0.1 EU\/μg of the protein by LAL method.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"10ug","offer_id":45198268596403,"sku":"RP01835-10","price":210.0,"currency_code":"CAD","in_stock":true},{"title":"20ug","offer_id":45198268629171,"sku":"RP01835-20","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"50ug","offer_id":45198268661939,"sku":"RP01835-50","price":350.0,"currency_code":"CAD","in_stock":true},{"title":"100ug","offer_id":45198268694707,"sku":"RP01835-100","price":560.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_738282c8-9621-4aa4-81d6-57bd0ac2ffcc.png?v=1766959929","url":"https:\/\/afsbio.com\/products\/recombinant-mouse-il-31-protein-rp01835","provider":"AFSBio Inc.","version":"1.0","type":"link"}