{"product_id":"recombinant-mouse-il-36-gamma-proteinn-hisactive-pksm041481","title":"Recombinant Mouse IL-36 gamma protein(N-His)(active) - PKSM041481","description":"Recombinant Mouse IL-36 gamma protein(N-His)(active)\n\nSizes: 20μg, 100μg\n\nCatalogue Numbers: PKSM041481-20, PKSM041481-100\n\nCitations, Manuals and MSDS Available upon request.\n\nAbbreviation: IL-36 gamma\n\nTarget Symptom: IL-17E\n\nTarget Species: Mouse\n\nExpression Host: E.coli\n\nApplication: Cell culture\n\nFusion Tag: N-His\n\nUNIProt ID: Q3U0P4\n\nAccession: Q3U0P4\n\nBackground: Interleukin-36 gamma (IL-36γ) is a member of the interleukin 1 cytokine family that includes three closely related genes, IL-36α, β, and γ, formerly known as IL-1F6, F8, and F9 respectively. IL-36α has been detected in both neuronal and synovial tissue, whereas IL-36β and IL-36γ are expressed in both cutaneous and mucosal epithelial cells, including the respiratory tract. IL-36β and IL-36γ stimulate proliferation, maturation and\/or cytokine expression by innate immune cells (such as keratinocytes and dendritic cells), and adaptive immune cells (neutrophils and T-cells) in both humans and mice. The activity of IL-36α is mediated by interleukin 1 receptor-like 2 (IL1RL2\/IL1R-rp2), and is specifically inhibited by interleukin 1 family, member 5 (IL1F5\/IL-1 delta). IL-36γ plays an important role in communicating the cell death to surrounding cells.\n\nActivity: Measure by its ability to induce IL-6 secretion in 3T3 cells. The ED50 for this effect is \u0026lt; 15 ng\/mL. The specific activity of recombinant mouse IL-36 gamma is \u0026gt; 6 x 10\u003csup\u003e4\u003c\/sup\u003eIU\/mg.\n\nSequence: MENNEKKNIVYGSDVEMEHERAGLFVSSAMFSKHPFSTHISGRETPDFGEVFDLDQQVWIFRNQALVTVPRSHRVTPVSVTILPCKYPESLEQDKGIAIYLGIQNPDKCLFCKEVNGHPTLLLKEEKILDLYHHPEPMKPFLFYHTRTGGTSTFESVAFPGHYIASSKTGNPIFLTSKKGEYYNINFNLDIKS\n\nPurity: \u0026gt; 98 % as determined by reducing SDS-PAGE.\n\nFormulation: Lyophilized from sterile PBS, pH 7.4\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\nPlease refer to the specific buffer information in the printed manual.\n\nReconstitution: Please refer to the printed manual for detailed information.\n\nEndotoxin: \u0026lt; 0.1 EU per μg of the protein as determined by the LAL method.\n\nCalculated MW: 22.83 kDa\n\nStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\n\nShipping: This product is provided as lyophilized powder which is shipped with ice packs.\n\nResearch Use Only","brand":"Elabscience","offers":[{"title":"20μg","offer_id":43118180466867,"sku":"PKSM041481-20","price":348.6,"currency_code":"CAD","in_stock":true},{"title":"100μg","offer_id":43118180499635,"sku":"PKSM041481-100","price":1034.6,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_94955ce6-2526-4234-a577-edb78d4140f1.png?v=1709637630","url":"https:\/\/afsbio.com\/products\/recombinant-mouse-il-36-gamma-proteinn-hisactive-pksm041481","provider":"AFSBio Inc.","version":"1.0","type":"link"}