{"product_id":"recombinant-mouse-il-36ra-il-1f5-protein-rp01809","title":"Recombinant Mouse IL-36Ra\/IL-1F5 Protein - RP01809","description":"\u003cp\u003eRecombinant Mouse IL-36Ra\/IL-1F5 Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10ug, 20g, 50ug, 100ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RP01809-10, RP01809-20, RP01809-50, RP01809-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Mouse IL-36Ra\/IL-1F5 Protein is produced by E. coli expression system. The target protein is expressed with sequence (Val3-Asp156) of mouse IL-36Ra\/IL-1F5 (Accession #NP_062324.2) fused with no additional amino acid.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: Il1f5; If36rn; Il-1h3; Il1hy1; IL-36Ra; Fil1delta\u003c\/p\u003e\n\n\u003cp\u003eSWISS: Q9QYY1\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 54450\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Mouse\u003c\/p\u003e\n\n\u003cp\u003ePurity: ≥ 95 % as determined by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20 ℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Interleukin-1 family member 5 (IL-1F5), also known as interleukin 36 receptor antagonist (IL36RA), is a member of the interleukin 1 cytokine family. This cytokine was shown to specifically inhibit the activation of NF-kappaB induced by interleukin 1 family, member 6 (IL1F6). IL-1F5 is a highly and specific antagonist of the IL-1 receptor-related protein 2-mediated response to interleukin 1 family member 9 (IL1F9). IL-1F5 could constitute part of an independent signaling system analogous to interleukin-1 alpha (IL-1A), beta (IL-1B) receptor agonist, and interleukin-1 receptor type I (IL-1R1), which is present in epithelial barriers and takes part in the local inflammatory response. It has been proved that IL-1F5 induces IL-4 mRNA and protein expression in glia in vitro and enhances hippocampal expression of IL-4 following intracerebroventricular injection. The inhibitory effect of IL-1F5 on LPS-induced IL-1β is attenuated in cells from IL-4-defective mice. Experiment results suggest that IL-1F5 mediates anti-inflammatory effects through its ability to induce IL-4 production and that this is a consequence of its interaction with the orphan receptor, single Ig IL-1R-related molecule (SIGIRR)\/TIR8, as the effects were not observed in SIGIRR-\/- mice. In contrast to its effects in brain tissue, IL-1F5 did not attenuate LPS-induced changes, or up-regulated IL-4 in macrophages or dendritic cells, suggesting that the effect is confined to the brain.\u003c\/p\u003e\n\n\u003cp\u003eSource: E. coli\u003c\/p\u003e\n\n\u003cp\u003eTag: NO-tag\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.\u003c\/p\u003e\n\n\u003cp\u003eAntigen Sequence: VLSGALCFRMKDSALKVLYLHNNQLLAGGLHAEKVIKGEEISVVPNRALDASLSPVILGVQGGSQCLSCGTEKGPILKLEPVNIMELYLGAKESKSFTFYRRDMGLTSSFESAAYPGWFLCTSPEADQPVRLTQIPEDPAWDAPITDFYFQQCD\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1 EU\/μg of the protein by LAL method.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"10ug","offer_id":45198268072115,"sku":"RP01809-10","price":196.0,"currency_code":"CAD","in_stock":true},{"title":"20ug","offer_id":45198268104883,"sku":"RP01809-20","price":266.0,"currency_code":"CAD","in_stock":true},{"title":"50ug","offer_id":45198268137651,"sku":"RP01809-50","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"100ug","offer_id":45198268170419,"sku":"RP01809-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_2aa71c37-bc4b-4dc9-8083-fb8d924b7963.png?v=1766959924","url":"https:\/\/afsbio.com\/products\/recombinant-mouse-il-36ra-il-1f5-protein-rp01809","provider":"AFSBio Inc.","version":"1.0","type":"link"}