{"product_id":"recombinant-mouse-il-4-protein-rp01161","title":"Recombinant Mouse IL-4 Protein - RP01161","description":"\u003cp\u003eRecombinant Mouse IL-4 Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10ug, 20g, 50ug, 100ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RP01161-10, RP01161-20, RP01161-50, RP01161-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Mouse IL-4 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (His23-Ser140) of mouse IL-4 (Accession #NP_067258.1) fused with a 6×His tag at the C-terminus.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: Il-4, BSF-1, IL4\u003c\/p\u003e\n\n\u003cp\u003eSWISS: P07750\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 16189\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Mouse\u003c\/p\u003e\n\n\u003cp\u003ePurity: ≥ 95 % as determined by SDS-PAGE; ≥ 95 % as determined by HPLC.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20 ℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Interleukin-4, also known as IL4, is a secreted protein that belongs to the IL-4 \/ IL-13 family. Interleukin-4 \/ IL4 has many biological roles, including the stimulation of activated B-cell and T-cell proliferation. It enhances both secretion and cell surface expression of IgE and IgG1. Interleukin-4 \/ IL4 also regulates the expression of the low-affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Interleukin-4 is essential for the switching of B cells to IgE antibody production and the maturation of T helper (Th) cells toward the Th2 phenotype.\u003c\/p\u003e\n\n\u003cp\u003eBio-Activity: 1.Measured in a cell proliferation assay using MC\/9 2 mouse mast cells. The ED50 for this effect is 2.8-11.3 pg\/mL, corresponding to a specific activity of 8.85×10^7~3.57×10^8 units\/mg. 2.Measured in a cell proliferation assay using HT-2 mouse T cells. The ED50 for this effect is 1.18-4.70 ng\/mL, corresponding to a specific activity of 2.13×10^5 ~8.51×10^6 units\/mg.\u003c\/p\u003e\n\n\u003cp\u003eSource: HEK293 cells\u003c\/p\u003e\n\n\u003cp\u003eTag: C-His\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.\u003c\/p\u003e\n\n\u003cp\u003eAntigen Sequence: HGCDKNHLREIIGILNEVTGEGTPCTEMDVPNVLTATKNTTESELVCRASKVLRIFYLKHGKTPCLKKNSSVLMELQRLFRAFRCLDSSISCTMNESKSTSLKDFLESLKSIMQMDYS\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 0.1 EU\/μg of the protein by LAL method.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"10ug","offer_id":45198343897267,"sku":"RP01161-10","price":210.0,"currency_code":"CAD","in_stock":true},{"title":"20ug","offer_id":45198343930035,"sku":"RP01161-20","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"50ug","offer_id":45198343962803,"sku":"RP01161-50","price":350.0,"currency_code":"CAD","in_stock":true},{"title":"100ug","offer_id":45198343995571,"sku":"RP01161-100","price":560.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_c7287c11-04eb-43ef-bdfd-4788558d370b.png?v=1766960835","url":"https:\/\/afsbio.com\/products\/recombinant-mouse-il-4-protein-rp01161","provider":"AFSBio Inc.","version":"1.0","type":"link"}