{"product_id":"recombinant-mouse-il-4r-alpha-cd124-protein-rp01680","title":"Recombinant Mouse IL-4R alpha\/CD124 Protein - RP01680","description":"\u003cp\u003eRecombinant Mouse IL-4R alpha\/CD124 Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10ug, 20g, 50ug, 100ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RP01680-10, RP01680-20, RP01680-50, RP01680-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Mouse IL-4R alpha\/CD124 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ile 26 - Arg 233) of mouse IL4R (Accession #NP_001008700.1) fused with and a 6×His tag at the C-terminus.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: Il4r; CD124; IL-4R\u003c\/p\u003e\n\n\u003cp\u003eSWISS: P16382\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 16190\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Mouse\u003c\/p\u003e\n\n\u003cp\u003ePurity: ≥ 95 % as determined by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20 ℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\n\u003cp\u003eBackground: CD124, also known as the interleukin 4 receptor (IL4R), is a typeⅠ transmembrane protein that can regulate IgE antibody production in B cells through binding to interleukin 4 and interleukin 13 and promote differentiation of Th2 cells through binding to interleukin 4. The membrane-bound form of CD124 can be hydrolyzed to a soluble form which can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells.\u003c\/p\u003e\n\n\u003cp\u003eBio-Activity: Measured by its ability to inhibit the mIL-4-dependent proliferation of HT-2 mouse T cells. The ED50 for this effect is 0.5-2 μg\/mL in the presence of 5 ng\/mL of recombinant mouse IL-4(Catalog: RP01161).\u003c\/p\u003e\n\n\u003cp\u003eSource: HEK293 cells\u003c\/p\u003e\n\n\u003cp\u003eTag: C-6His\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.\u003c\/p\u003e\n\n\u003cp\u003eAntigen Sequence: IKVLGEPTCFSDYIRTSTCEWFLDSAVDCSSQLCLHYRLMFFEFSENLTCIPRNSASTVCVCHMEMNRPVQSDRYQMELWAEHRQLWQGSFSPSGNVKPLAPDNLTLHTNVSDEWLLTWNNLYPSNNLLYKDLISMVNISREDNPAEFIVYNVTYKEPRLSFPINILMSGVYYTARVRVRSQILTGTWSEWSPSITWYNHFQLPLIQR\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 0.1 EU\/μg of the protein by LAL method.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"10ug","offer_id":45198336098483,"sku":"RP01680-10","price":182.0,"currency_code":"CAD","in_stock":true},{"title":"20ug","offer_id":45198336131251,"sku":"RP01680-20","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"50ug","offer_id":45198336164019,"sku":"RP01680-50","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"100ug","offer_id":45198336196787,"sku":"RP01680-100","price":420.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_246919a1-4203-4b0e-ad83-0930c6cc389e.png?v=1766960739","url":"https:\/\/afsbio.com\/products\/recombinant-mouse-il-4r-alpha-cd124-protein-rp01680","provider":"AFSBio Inc.","version":"1.0","type":"link"}