{"product_id":"recombinant-mouse-il-6ra-cd126-protein-rp01862","title":"Recombinant Mouse IL-6RA\/CD126 Protein - RP01862","description":"\u003cp\u003eRecombinant Mouse IL-6RA\/CD126 Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10ug, 20g, 50ug, 100ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RP01862-10, RP01862-20, RP01862-50, RP01862-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Mouse IL-6RA\/CD126 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Leu 20 - Glu 357) of Mouse Il6ra (Accession #NP_034689.2) fused with His tag at the C-terminus.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: IL-6 receptor subunit alpha; IL-6R subunit alpha; IL-6R-alpha; IL-6RA; CD126; Il6ra; Il6r\u003c\/p\u003e\n\n\u003cp\u003eSWISS: P22272\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 16194\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Mouse\u003c\/p\u003e\n\n\u003cp\u003ePurity: ≥ 90% as determined by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20 ℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\n\u003cp\u003eBackground: IL-6R alpha (IL-6RA) is a subunit alpha of IL-6 receptors, also shared by other interleukin receptors. IL-6RA is a type I transmembrane glycoprotein, which forms a complex with the type I transmembrane signal transducer Glycoprotein 130 (CD130) and regulates the biological activity of IL-6 with a low affinity. IL-6RA acts as IL-6 agonist and involves in JAK\/STAT, MAPK, and Akt signaling pathway. IL-6RA has 2 isoform including mIL-6R (the longer one) or sIL-6R (the shorter one): The mIL-6R is membrane-bound interleukin-6 receptor, has the potential to drive naive CD4+ T cells to the Th17 lineage, through 'cluster signaling' by dendritic cells. The sIL-6R is soluble interleukin-6 receptor subunit, cleaved from IL-6RA in activated CD4+ T cells by proteolysis, and serves as IL-6 agonist. sIL-6R binds membrane-bound IL-6R and subunit IL6ST to activate regenerative and anti-inflammatory signal via IL-6 trans signaling and promotes pro-inflammatory properties of IL-6. The hydrolysis of IL-6R alpha is also called ectodomain shedding. IL-6RA involves in regulating cell growth and differentiation, and plays an important role in regulation of immune response, acute-phase reactions and hematopoiesis. However, IL-6RA shows tissue expression specificity in liver and some cells of the immune system, thus results a limitation of IL6 signaling. It's worth noting that IL-6RA dysregulation is implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases, and prostate cancer.\u003c\/p\u003e\n\n\u003cp\u003eSource: HEK293 cells\u003c\/p\u003e\n\n\u003cp\u003eTag: C-His\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.\u003c\/p\u003e\n\n\u003cp\u003eAntigen Sequence: LVLGSCRALEVANGTVTSLPGATVTLICPGKEAAGNVTIHWVYSGSQNREWTTTGNTLVLRDVQLSDTGDYLCSLNDHLVGTVPLLVDVPPEEPKLSCFRKNPLVNAICEWRPSSTPSPTTKAVLFAKKINTTNGKSDFQVPCQYSQQLKSFSCQVEILEGDKVYHIVSLCVANSVGSKSSHNEAFHSLKMVQPDPPANLVVSAIPGRPRWLKVSWQHPETWDPSYYLLQFQLRYRPVWSKEFTVLLLPVAQYQCVIHDALRGVKHVVQVRGKEELDLGQWSEWSPEVTGTPWIAEPRTTPAGILWNPTQVSVEDSANHEDQYESSTEATSVLAPVQE\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 0.01 EU\/μg of the protein by LAL method\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"10ug","offer_id":45198266237107,"sku":"RP01862-10","price":210.0,"currency_code":"CAD","in_stock":true},{"title":"20ug","offer_id":45198266269875,"sku":"RP01862-20","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"50ug","offer_id":45198266302643,"sku":"RP01862-50","price":350.0,"currency_code":"CAD","in_stock":true},{"title":"100ug","offer_id":45198266335411,"sku":"RP01862-100","price":560.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_f3458ad5-2b27-4ffc-b7e9-bcd2a246bdda.png?v=1766959904","url":"https:\/\/afsbio.com\/products\/recombinant-mouse-il-6ra-cd126-protein-rp01862","provider":"AFSBio Inc.","version":"1.0","type":"link"}