{"product_id":"recombinant-mouse-il1rl1-st2-protein-rp01538","title":"Recombinant Mouse IL1RL1\/ST2 Protein - RP01538","description":"\u003cp\u003eRecombinant Mouse IL1RL1\/ST2 Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10ug, 20g, 50ug, 100ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RP01538-10, RP01538-20, RP01538-50, RP01538-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Mouse IL1RL1\/ST2 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ser27-Arg332) of mouse IL-1RL1\/ST2 (Accession #NP_001020773.1) fused with a 6×His tag at the C-terminus.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: DER4 , FIT-1 , IL1RL1 , IL33R , IL?1?R4 , ST2 , ST2L , ST2V , T1, IL1RL1\u003c\/p\u003e\n\n\u003cp\u003eSWISS: P14719\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 17082\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Mouse\u003c\/p\u003e\n\n\u003cp\u003ePurity: ≥ 95 % as determined by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20 ℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\n\u003cp\u003eBackground: IL-1 receptor–like 1 (IL1RL1) is a membrane receptor involved in TH2 inflammatory responses and eosinophilia. It has previously been described that levels of the interleukin-1 like 1 (IL1RL1) protein can be used to diagnose cardiovascular disease and determine the prognosis for a patient with cardiovascular disease. The ligand for IL1RL1 has been described and named IL-33. Mutants in IL1RL1 have been associated with blood eosinophil counts in a genome-wide association study and with asthma in family-based and case-control studies. As an important mediator involved in many immune and inflammatory responses, this cytokine has been implicated as a regulator of both the development and effector phases of type 2 helper T cell responses, and as a negative feedback modulator of macrophage proinflammatory function. IL33 is a specific ligand of ST2L and induces the production of Th2 cytokines.\u003c\/p\u003e\n\n\u003cp\u003eSource: HEK293 cells\u003c\/p\u003e\n\n\u003cp\u003eTag: C-His\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.\u003c\/p\u003e\n\n\u003cp\u003eAntigen Sequence: SKSSWGLENEALIVRCPQRGRSTYPVEWYYSDTNESIPTQKRNRIFVSRDRLKFLPARVEDSGIYACVIRSPNLNKTGYLNVTIHKKPPSCNIPDYLMYSTVRGSDKNFKITCPTIDLYNWTAPVQWFKNCKALQEPRFRAHRSYLFIDNVTHDDEGDYTCQFTHAENGTNYIVTATRSFTVEEKGFSMFPVITNPPYNHTMEVEIGKPASIACSACFGKGSHFLADVLWQINKTVVGNFGEARIQEEEGRNESSSNDMDCLTSVLRITGVTEKDLSLEYDCLALNLHGMIRHTIRLRRKQPIDHR\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 0.1 EU\/μg of the protein by LAL method.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"10ug","offer_id":45198256767155,"sku":"RP01538-10","price":196.0,"currency_code":"CAD","in_stock":true},{"title":"20ug","offer_id":45198256799923,"sku":"RP01538-20","price":266.0,"currency_code":"CAD","in_stock":true},{"title":"50ug","offer_id":45198256832691,"sku":"RP01538-50","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"100ug","offer_id":45198256865459,"sku":"RP01538-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_36ec6df3-0679-424d-a37d-8fbb9f61043f.png?v=1766959803","url":"https:\/\/afsbio.com\/products\/recombinant-mouse-il1rl1-st2-protein-rp01538","provider":"AFSBio Inc.","version":"1.0","type":"link"}