{"product_id":"recombinant-mouse-il1rl1-st2-protein-rp01673","title":"Recombinant Mouse IL1RL1\/ST2 Protein - RP01673","description":"\u003cp\u003eRecombinant Mouse IL1RL1\/ST2 Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10ug, 20g, 50ug, 100ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RP01673-10, RP01673-20, RP01673-50, RP01673-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Mouse IL1RL1\/ST2 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ser27-Ala332) of mouse IL1RL1 (Accession #NP_001020773.1) fused with and a hFc tag at the C-terminus.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: T1; St2; DER4; Ly84; ST2L; Fit-1; T1\/ST2; St2-rs1; IL1RL1\u003c\/p\u003e\n\n\u003cp\u003eSWISS: P14719\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 17082\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Mouse\u003c\/p\u003e\n\n\u003cp\u003ePurity: ≥ 90 % as determined by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20 ℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\n\u003cp\u003eBackground: IL-1 receptor–like 1 (IL1RL1) is a membrane receptor involved in TH2 inflammatory responses and eosinophilia. It has previously been described that levels of the interleukin-1 like 1 (IL1RL1) protein can be used to diagnose cardiovascular disease and determine the prognosis for a patient with cardiovascular disease. The ligand for IL1RL1 has been described and named IL-33. Mutants in IL1RL1 have been associated with blood eosinophil counts in a genome-wide association study and with asthma in family-based and case-control studies. As an important mediator involved in many immune and inflammatory responses, this cytokine has been implicated as a regulator of both the development and effector phases of type 2 helper T cell responses, and as a negative feedback modulator of macrophage proinflammatory function. IL33 is a specific ligand of ST2L and induces the production of Th2 cytokines.\u003c\/p\u003e\n\n\u003cp\u003eBio-Activity: Measured by its binding ability in a functional ELISA. Immobilized mouse IL-33 (Catalog: RP01802) at 10 μg\/mL (100 μL\/well) can bind mouse IL1RL1 (Catalog: RP01673) with a linear range of 19.5-1197.7 ng\/mL.\u003c\/p\u003e\n\n\u003cp\u003eSource: HEK293 cells\u003c\/p\u003e\n\n\u003cp\u003eTag: C-hFc\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.\u003c\/p\u003e\n\n\u003cp\u003eAntigen Sequence: SKSSWGLENEALIVRCPQRGRSTYPVEWYYSDTNESIPTQKRNRIFVSRDRLKFLPARVEDSGIYACVIRSPNLNKTGYLNVTIHKKPPSCNIPDYLMYSTVRGSDKNFKITCPTIDLYNWTAPVQWFKNCKALQEPRFRAHRSYLFIDNVTHDDEGDYTCQFTHAENGTNYIVTATRSFTVEEKGFSMFPVITNPPYNHTMEVEIGKPASIACSACFGKGSHFLADVLWQINKTVVGNFGEARIQEEEGRNESSSNDMDCLTSVLRITGVTEKDLSLEYDCLALNLHGMIRHTIRLRRKQPIDHR\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 0.1 EU\/μg of the protein by LAL method.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"10ug","offer_id":45198333018291,"sku":"RP01673-10","price":196.0,"currency_code":"CAD","in_stock":true},{"title":"20ug","offer_id":45198333051059,"sku":"RP01673-20","price":266.0,"currency_code":"CAD","in_stock":true},{"title":"50ug","offer_id":45198333083827,"sku":"RP01673-50","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"100ug","offer_id":45198333116595,"sku":"RP01673-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_43db231b-16c3-4f3d-8fe9-09d766f99293.png?v=1766960701","url":"https:\/\/afsbio.com\/products\/recombinant-mouse-il1rl1-st2-protein-rp01673","provider":"AFSBio Inc.","version":"1.0","type":"link"}