{"product_id":"recombinant-mouse-il2rg-cd132-protein-his-fc-tagactive-pksm040876","title":"Recombinant Mouse IL2RG\/CD132 Protein (His \u0026 Fc Tag)(Active) - PKSM040876","description":"Recombinant Mouse IL2RG\/CD132 Protein (His \u0026amp; Fc Tag)(Active)\n\nSize: 100μg\n\nCatalogue Number: PKSM040876-100\n\nCitations, Manuals and MSDS Available upon request.\n\nAbbreviation: IL2RG; CD132\n\nTarget Symptom: CD132; gamma(c); gc\n\nTarget Species: Mouse\n\nExpression Host: HEK293 Cells\n\nApplication: ELISA\n\nFusion Tag: C-His-Fc\n\nAccession: NP_038591.1\n\nBackground: The common gamma chain (γ c) (or CD132), also known as interleukin-2 receptor subunit gamma or IL2RG, is a member of the type I cytokine receptor family expressed on most lymphocyte (white blood cell) populations, and its gene is found on the X-chromosome of mammals. The common gamma chain (γ c) (or IL2RG), is a cytokine receptor sub-unit that is common to the receptor complexes for at least six different interleukin receptors: IL-2, IL-4, IL-7, IL-9, IL-15 and interleukin-21 receptor. It is a component of multiple cytokine receptors that are essential for lymphocyte development and function. X-linked severe combined immunodeficiency (XSCID) is a rare and potentially fatal disease caused by mutations of IL2RG, the gene encoding IL2RG. IL2RG was demonstrated to be a component of the IL-4 receptor on the basis of chemical cross-linking data, the ability of IL2RG to augment IL-4 binding affinity. The observation that IL-2R gamma is a functional component of the IL-4 receptor, together with the finding that IL-2R gamma associates with the IL-7 receptor, begins to elucidate why deficiency of this common gamma chain (gamma c) has a profound effect on lymphoid function and development, as seen in X-linked severe combined immunodeficiency.\n\nActivity: Measured by its ability to bind biotinylated recombinant rat IL2 in a functional ELISA.\n\nSequence: Met 1-Ala 263\n\nPurity: \u0026gt; 92 % as determined by reducing SDS-PAGE.\n\nFormulation: Lyophilized from sterile PBS, pH 7.4\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\nPlease refer to the specific buffer information in the printed manual.\n\nReconstitution: Please refer to the printed manual for detailed information.\n\nEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\n\nCalculated MW: 56.3 kDa\n\nObserved MW: 75-85 kDa\n\nStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\n\nShipping: This product is provided as lyophilized powder which is shipped with ice packs.\n\nResearch Use Only","brand":"Elabscience","offers":[{"title":"Default Title","offer_id":43104276676787,"sku":"PKSM040876-100","price":1024.8,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_2f2d7ade-75c7-4b6f-bb31-ea570926d23e.png?v=1709293574","url":"https:\/\/afsbio.com\/products\/recombinant-mouse-il2rg-cd132-protein-his-fc-tagactive-pksm040876","provider":"AFSBio Inc.","version":"1.0","type":"link"}