{"product_id":"recombinant-mouse-il6st-cd130-protein-his-tagactive-pksm040841","title":"Recombinant Mouse IL6ST\/CD130 Protein (His Tag)(Active) - PKSM040841","description":"\u003cp\u003eRecombinant Mouse IL6ST\/CD130 Protein (His Tag)(Active)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μg, 100μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSM040841-20, PKSM040841-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: IL6ST; CD130\u003c\/p\u003e\n\n\u003cp\u003eTarget Symptom: 5133400A03Rik; AA389424; BB405851; CD130; D13Ertd699e; gp130\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Mouse\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: HEK293 Cells\u003c\/p\u003e\n\n\u003cp\u003eApplication: ELISA\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: C-His\u003c\/p\u003e\n\n\u003cp\u003eAccession: NP_034690.3\u003c\/p\u003e\n\n\u003cp\u003eBackground: Glycoprotein 130 (also known as gp130, IL6ST, IL6-beta or CD130) is a transmembrane protein which is the founding member of the class of all cytokine receptors. CD130\/gp130 is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and Oncostatin M (OSM). CD130\/gp130 functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. CD130\/gp130 plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. A related pseudogene has been identified on chromosome 17. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. CD130\/gp130 binds to IL6\/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. CD130\/gp130 may have a role in embryonic development. The type I OSM receptor is capable of transducing OSM-specific signaling events.\u003c\/p\u003e\n\n\u003cp\u003eActivity: 1. Measured by its ability to bind mouse IL11Ra in a functional ELISA. \u003cbr\u003e\n2. Measured by its ability to inhibit the IL6 Rα enhancement of IL6 activity on M1 mouse myeloid leukemia cells. The ED50 for this effect is typically 0.6-3 μg\/mL in the presence of 10 ng\/mL recombinant human IL6 sR and 20 ng\/mL recombinant human IL6.\u003c\/p\u003e \n\n\u003cp\u003eSequence: Met 1-Glu 617\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 97 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from sterile PBS, pH 7.4\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 68 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 80-90 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"20μg","offer_id":43114020077747,"sku":"PKSM040841-20","price":576.8,"currency_code":"CAD","in_stock":true},{"title":"100μg","offer_id":43114020110515,"sku":"PKSM040841-100","price":1127.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_4d9a38f9-1938-4a37-a91c-6047c59216a2.png?v=1709550320","url":"https:\/\/afsbio.com\/products\/recombinant-mouse-il6st-cd130-protein-his-tagactive-pksm040841","provider":"AFSBio Inc.","version":"1.0","type":"link"}