{"product_id":"recombinant-mouse-interleukin-17-il-17-protein-active-pksm040953","title":"Recombinant Mouse Interleukin-17\/IL-17 Protein (Active) - PKSM040953","description":"\u003cp\u003eRecombinant Mouse Interleukin-17\/IL-17 Protein (Active)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μg, 100μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSM040953-20, PKSM040953-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: Interleukin-17; IL-17\u003c\/p\u003e\n\n\u003cp\u003eTarget Symptom: Ctla-8; Ctla8; IL-17; IL-17A; Il17\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Mouse\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: E.coli\u003c\/p\u003e\n\n\u003cp\u003eApplication: ELISA\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: None\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: Q62386\u003c\/p\u003e\n\n\u003cp\u003eAccession: Q62386\u003c\/p\u003e\n\n\u003cp\u003eBackground: IL17, also known as IL17a, is a cytokine belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival\/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. The IL-17 family of cytokines includes six members, IL-17\/IL-17A, IL-17B, IL-17C, IL-17D, IL-17E\/IL-25, and IL-17F, which are produced by multiple cell types. IL-17 regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2\/COX-2), as well as enhance the production of nitric oxide (NO). High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.\u003c\/p\u003e\n\n\u003cp\u003eActivity: Immobilized recombinant mouse IL17a at 10 μg\/mL (100 μl\/well) can bind human IL17Ra-Fc2h with a linear range of 16-500 ng\/mL.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Thr 22-Ala158\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 97 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from sterile PBS, pH 7.4\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: Please contact us for more information.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 15.5 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 16 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"20μg","offer_id":43114030203059,"sku":"PKSM040953-20","price":348.6,"currency_code":"CAD","in_stock":true},{"title":"100μg","offer_id":43114030235827,"sku":"PKSM040953-100","price":1034.6,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_b07ff8d8-7a10-4adc-aa8b-b5bfa7ed0007.png?v=1709550511","url":"https:\/\/afsbio.com\/products\/recombinant-mouse-interleukin-17-il-17-protein-active-pksm040953","provider":"AFSBio Inc.","version":"1.0","type":"link"}