{"product_id":"recombinant-mouse-interleukin-21-il-21-protein-his-tag-pksm041083","title":"Recombinant Mouse Interleukin-21\/IL-21 Protein (His Tag) - PKSM041083","description":"\u003cp\u003eRecombinant Mouse Interleukin-21\/IL-21 Protein (His Tag)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10μg, 50μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSM041083-10, PKSM041083-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: Interleukin-21; IL-21\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: Interleukin-21; IL-21; IL21; Il21\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: Q9ES17\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Mouse\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: E.coli\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: N-6His\u003c\/p\u003e\n\n\u003cp\u003eAccession: Q9ES17\u003c\/p\u003e\n\n\u003cp\u003eBackground: Interleukin-21(IL-21) is an approximately 14 kDa cytokine which belongs to the IL-15\/IL-21 family. Mature mouse IL-21 shares 66%, 59%, 58%, and 88% aa sequence identity with mature canine, human, rabbit, and rat IL-21, respectively. IL-21 is produced by activated T follicular helper cells (Tfh), Th17 cells, and NKT cells. It exerts its biological effects through a heterodimeric receptor complex (IL-21 specific IL-21 R). IL-21 is a cytokine that has potent regulatory effects on cells of the immune system, including natural killer (NK) cells and cytotoxic T cells that can destroy virally infected or cancerous cells. This cytokine induces cell division\/proliferation in its target cells. It is required for the migration of dendritic cells to draining lymph nodes.It co-stimulates the activation, proliferation, and survival of CD8+ T cells and NKT cells and promotes Th17 cell polarization. It blocks the generation of regulatory T cells and their suppressive effects on CD4+ T cells.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Pro25-Ser146\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.2 μm filtered solution of 20mM Histidine-HCl, 6% Sucrose, 2% Glycine, 50mM NaCl, 0.05% Tween 80, pH 6.5.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 16.5 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 16 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"10μg","offer_id":43072198607027,"sku":"PKSM041083-10","price":249.2,"currency_code":"CAD","in_stock":true},{"title":"50μg","offer_id":43072198639795,"sku":"PKSM041083-50","price":732.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_55ad6238-1a6f-4dff-bda4-00bdeb24a114.png?v=1708683742","url":"https:\/\/afsbio.com\/products\/recombinant-mouse-interleukin-21-il-21-protein-his-tag-pksm041083","provider":"AFSBio Inc.","version":"1.0","type":"link"}