{"product_id":"recombinant-mouse-interleukin-22-il-22-protein-mfc-tag-pksm041084","title":"Recombinant Mouse Interleukin-22\/IL-22 Protein (mFc Tag) - PKSM041084","description":"\u003cp\u003eRecombinant Mouse Interleukin-22\/IL-22 Protein (mFc Tag)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10μg, 50μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSM041084-10, PKSM041084-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: Interleukin-22; IL-22\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: Interleukin-22; IL-22; IL-TIF alpha; IL-10-related T-cell-derived-inducible factor; IL-TIF; IL22; Interleukin-22a; IL-22a\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: Q9JJY9\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Mouse\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: HEK293 Cells\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: C-mFc\u003c\/p\u003e\n\n\u003cp\u003eAccession: Q9JJY9\u003c\/p\u003e\n\n\u003cp\u003eBackground: Interleukin-22 (IL-22) was initially identified as a gene induced by IL-9 in mouse T cells and mast cells. Mouse IL-22 cDNA encodes a 179 amino acid residue protein with a putative 33 amino acid signal peptide that is cleaved to generate a 147 amino acid mature protein that shares approximately 79% and 22% sequence identity with human IL22 and IL10, respectively. IL22 has been shown to activate STAT-1 and STAT-3 in several hepatoma cell lines and up-regulate the production of acute phase proteins. IL-22 is produced by normal mouse T cells upon Con A activation. Mouse IL-22 expression is also induced in various organs upon lipopolysaccharide injection, suggesting that IL-22 may be involved in inflammatory responses. The functional IL-22 receptor complex consists of two receptor subunits, IL-22R (previously an orphan receptor named CRF2-9) and IL-10Rβ (previously known as CRF2-4), belonging to the class II cytokine receptor family.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Leu34-Val179\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 43.8 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 50-65 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"10μg","offer_id":43072198672563,"sku":"PKSM041084-10","price":180.6,"currency_code":"CAD","in_stock":true},{"title":"50μg","offer_id":43072198705331,"sku":"PKSM041084-50","price":525.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_e8107429-e321-4e35-a396-7f825a5b0908.png?v=1708683745","url":"https:\/\/afsbio.com\/products\/recombinant-mouse-interleukin-22-il-22-protein-mfc-tag-pksm041084","provider":"AFSBio Inc.","version":"1.0","type":"link"}