{"product_id":"recombinant-mouse-kallikrein-1-klk1-protein-his-tag-pksm041314","title":"Recombinant Mouse Kallikrein 1\/KLK1 Protein (His Tag) - PKSM041314","description":"\u003cp\u003eRecombinant Mouse Kallikrein 1\/KLK1 Protein (His Tag)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10μg, 50μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSM041314-10, PKSM041314-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: Kallikrein 1; KLK1\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: Glandular kallikrein K1; KAL-B; Renal kallikrein; Tissue kallikrein-6; mGK-6\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: P15947\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Mouse\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: HEK293 Cells\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: C-His\u003c\/p\u003e\n\n\u003cp\u003eAccession: P15947\u003c\/p\u003e\n\n\u003cp\u003eBackground: Kallikreins belongs to the family of trypsin-like serine proteases, many of which are associated with a variety of cancers. Kallikrein 1 (KLK1) is also known as tissue kallikrein and urinary kallikrein. KLK1 is synthesized as a 261 amino acid (aa) protein that contains a 18 aa signal peptide and a 241 aa proprotein. An important physiological function of KLK1 cleaves Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin. Kinins regulate vasodilation, blood pressure reduction, smooth muscle relaxation and contraction, pain induction and inflammation.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Pro19-Asp261\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.2 μm filtered solution of 20mM Tris, 150mM NaCl, pH7.5.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 27.9 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 34-38 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"10μg","offer_id":43072213483699,"sku":"PKSM041314-10","price":249.2,"currency_code":"CAD","in_stock":true},{"title":"50μg","offer_id":43072213516467,"sku":"PKSM041314-50","price":732.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_ad030669-ba10-4630-bae9-5ec790681fd5.png?v=1708684210","url":"https:\/\/afsbio.com\/products\/recombinant-mouse-kallikrein-1-klk1-protein-his-tag-pksm041314","provider":"AFSBio Inc.","version":"1.0","type":"link"}