{"product_id":"recombinant-mouse-lag-3-cd223-protein-rp01327","title":"Recombinant Mouse LAG-3\/CD223 Protein - RP01327","description":"\u003cp\u003eRecombinant Mouse LAG-3\/CD223 Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10ug, 20g, 50ug, 100ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RP01327-10, RP01327-20, RP01327-50, RP01327-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Mouse LAG-3\/CD223 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gly24-Leu442) of Mouse LAG3 (Accession #NP_032505.1) fused with an 6×His tag at the C-terminus.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: LAG3, CD223, FDC, Ly66, LAG3\u003c\/p\u003e\n\n\u003cp\u003eSWISS: Q61790\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 16768\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Mouse\u003c\/p\u003e\n\n\u003cp\u003ePurity: ≥ 95 % as determined by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20 ℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\n\u003cp\u003eBackground: LAG3 (Lymphocyte Activating 3), also known as CD223 and Lymphocyte activation gene 3, belongs to the immunoglobulin (Ig) superfamily, is a protein-coding gene. 2 alternatively spliced human isoforms have been reported. The LAG3 gene contains 8 exons. It is selectively expressed in activated T and NK cells. LAG3 contains 4 extracellular Ig-like domains and has a negative regulatory function in T cells. It also acts as a new marker of T cell-induced B cell activation. As a soluble molecule, LAG3 activates antigen-presenting cells through MHC class II signaling, leading to increased antigen-specific T-cell responses in vivo. Diseases associated with LAG3 include Smoldering Myeloma and Kyphoscoliotic Heart Disease.\u003c\/p\u003e\n\n\u003cp\u003eBio-Activity: Measured by its binding ability in a functional ELISA.Immobilized Mouse LAG3 (Catalog: RP01327) at 1 μg\/mL (100 μL\/well) can bind LAG3 Rabbit pAb with a linear range of 0.06-1.2ng\/mL.\u003c\/p\u003e\n\n\u003cp\u003eSource: HEK293 cells\u003c\/p\u003e\n\n\u003cp\u003eTag: C-His\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.\u003c\/p\u003e\n\n\u003cp\u003eAntigen Sequence: GPGKELPVVWAQEGAPVHLPCSLKSPNLDPNFLRRGGVIWQHQPDSGQPTPIPALDLHQGMPSPRQPAPGRYTVLSVAPGGLRSGRQPLHPHVQLEERGLQRGDFSLWLRPALRTDAGEYHATVRLPNRALSCSLRLRVGQASMIASPSGVLKLSDWVLLNCSFSRPDRPVSVHWFQGQNRVPVYNSPRHFLAETFLLLPQVSPLDSGTWGCVLTYRDGFNVSITYNLKVLGLEPVAPLTVYAAEGSRVELPCHLPPGVGTPSLLIAKWTPPGGGPELPVAGKSGNFTLHLEAVGLAQAGTYTCSIHLQGQQLNATVTLAVITVTPKSFGLPGSRGKLLCEVTPASGKERFVWRPLNNLSRSCPGPVLEIQEARLLAERWQCQLYEGQRLLGATVYAAESSSGAHSARRISGDLKGGHL\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 0.1 EU\/μg of the protein by LAL method.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"10ug","offer_id":45198308606131,"sku":"RP01327-10","price":196.0,"currency_code":"CAD","in_stock":true},{"title":"20ug","offer_id":45198308638899,"sku":"RP01327-20","price":266.0,"currency_code":"CAD","in_stock":true},{"title":"50ug","offer_id":45198308671667,"sku":"RP01327-50","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"100ug","offer_id":45198308704435,"sku":"RP01327-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_c2f1d975-c1e5-424d-a6b2-6de1148fc983.png?v=1766960432","url":"https:\/\/afsbio.com\/products\/recombinant-mouse-lag-3-cd223-protein-rp01327","provider":"AFSBio Inc.","version":"1.0","type":"link"}