{"product_id":"recombinant-mouse-mature-beta-nerve-growth-factor-ngfb-protein-rp00667","title":"Recombinant Mouse Mature Beta-nerve growth factor\/NGFB Protein - RP00667","description":"\u003cp\u003eRecombinant Mouse Mature Beta-nerve growth factor\/NGFB Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10ug, 20ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: RP00667-10, RP00667-20\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Mouse Beta-nerve growth factor\/NGFB Protein is produced by E. coli expression system. The target protein is expressed with sequence (Ser122-Gly241) of Mouse Beta-nerve growth factor\/NGFB (Accession #P01139) fused with no tag.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: Beta-Nerve Growth Factor, Beta-NGF, NGF, NGFB\u003c\/p\u003e\n\n\u003cp\u003eSWISS: P01139\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 18049\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Mouse\u003c\/p\u003e\n\n\u003cp\u003ePurity: ≥ 95 % as determined by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\n\u003cp\u003eBackground: NGF is the first member discovered in the Neurotrophin family, which includes brain-derived neurotrophicfactor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4). These proteins belong to the cysteine-knotfamily of growth factors that assume stable dimeric structures. Mouse beta -NGF is a homodimer of two 120amino acid polypeptides. It shares approximately 90% homology at the amino acid level with human beta -NGFand 95.8% with rat beta -NGF. NGF signaling has been shown to play an important role in neuroprotection andrepair. β-NGF acts as a growth and differentiation factor for B lymphocytes, and enhances B-cell survival. It is apotent neurotrophic factor that signals through its receptor β -NGFR, and plays a crucial role in thedevelopment and preservation of the sensory and sympathetic nervous systems.\u003c\/p\u003e\n\n\u003cp\u003eBio-Activity: Measured in a cell proliferation assay using TF-1 Human erythroleukemic cells. The ED50 for this effect is 0.63-2.53 ng\/mL, corresponding to a specific activity of 3.95×10^5 ~1.58×10^6 units\/mg.\u003c\/p\u003e\n\n\u003cp\u003eSource: E. coli\u003c\/p\u003e\n\n\u003cp\u003eTag: No tag\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.2 μm filtered solution of 50mM NaAc,150mM NaCl,pH5.5.\u003c\/p\u003e\n\n\u003cp\u003eAntigen Sequence: SSTHPVFHMGEFSVCDSVSVWVGDKTTATDIKGKEVTVLAEVNINNSVFRQYFFETKCRASNPVESGCRGIDSKHWNSYCTTTHTFVKALTTDEKQAAWRFIRIDTACVCVLSRKATRRG\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 0.1 EU\/μg of the protein by LAL method.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"10ug","offer_id":45198350221491,"sku":"RP00667-10","price":182.0,"currency_code":"CAD","in_stock":true},{"title":"20ug","offer_id":45198350254259,"sku":"RP00667-20","price":252.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_159a0b12-bc4d-4815-a444-a5ec62fd27e7.png?v=1766960917","url":"https:\/\/afsbio.com\/products\/recombinant-mouse-mature-beta-nerve-growth-factor-ngfb-protein-rp00667","provider":"AFSBio Inc.","version":"1.0","type":"link"}