{"product_id":"recombinant-mouse-mek4-map2k4-protein-his-gst-tag-pksm040567","title":"Recombinant Mouse MEK4\/MAP2K4 Protein (His \u0026 GST Tag) - PKSM040567","description":"\u003cp\u003eRecombinant Mouse MEK4\/MAP2K4 Protein (His \u0026amp; GST Tag)\u003c\/p\u003e\n\n\u003cp\u003eSize: 50μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: PKSM040567-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: MEK4, MAP2K4\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: JNKK1, MEK4, MKK4, PRKMK4, Sek1, Serk1\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: P47809\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Mouse\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: Baculovirus-Insect Cells\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: N-His-GST\u003c\/p\u003e\n\n\u003cp\u003eAccession: P47809\u003c\/p\u003e\n\n\u003cp\u003eBackground: Dual specificity mitogen-activated protein kinase kinase 4, also known as MAP kinase kinase 4, MAPKK4, JNK-activating kinase 1, MAPK\/ERK kinase 4, SAPK\/ERK kinase 1, c-Jun N-terminal kinase kinase 1, JNKK and MAP2K4, is a protein which belongs to theprotein kinase superfamily, STE Ser\/Thr protein kinase family and MAP kinase kinase subfamily. MAP2K4 \/ JNKK1 is a protein kinase which is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. MAP2K4 \/ JNKK1 has been shown to activate MAPK8 \/ JNK1, MAPK9 \/ JNK2, and MAPK14 \/ p38, but not MAPK1 \/ ERK2 or MAPK3 \/ ERK1. MAP2K4 \/ JNKK1 is phosphorylated, and thus activated by MAP3K1 \/ MEKK. The stress-activated protein kinase (SAPK) pathways represent phosphorylation cascades that convey pro-apoptotic signals. The mitogen-activated protein kinase kinase (MAPKK) homolog MAP2K4 ( MKK4, SEK, JNKK1 ) is a centrally-placed mediator of the SAPK pathways.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Ala 2-Asp 397\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 90 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from sterile 20mM Tris, 500mM NaCl, pH 8.5\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 72 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 65 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"50μg","offer_id":43155010224307,"sku":"PKSM040567-50","price":680.4,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_ff16933d-41d6-407e-b5c2-9f6bbf03c74d.png?v=1710436217","url":"https:\/\/afsbio.com\/products\/recombinant-mouse-mek4-map2k4-protein-his-gst-tag-pksm040567","provider":"AFSBio Inc.","version":"1.0","type":"link"}