{"product_id":"recombinant-mouse-motch-a-notch1-protein-his-tag-pksm041299","title":"Recombinant Mouse Motch A\/NOTCH1 Protein (His Tag) - PKSM041299","description":"\u003cp\u003eRecombinant Mouse Motch A\/NOTCH1 Protein (His Tag)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10μg, 50μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSM041299-10, PKSM041299-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: Motch A; NOTCH1\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: Neurogenic locus notch homolog protein 1; Notch 1; Motch A; Mt14; lin-12; Mis6; N1; Tan1\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: Q01705\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Mouse\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: HEK293 Cells\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: C-His\u003c\/p\u003e\n\n\u003cp\u003eAccession: Q01705\u003c\/p\u003e\n\n\u003cp\u003eBackground: Mouse Notch1 is a 300 kDa type I transmembrane glycoprotein and it functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Mouse Notch1 is synthesized as a 2531 amino acid (aa) precursor that contains an 18 aa signal sequence, a 1707 aa extracellular domain (ECD) with 36 EGFlike repeats and three Lin12\/notch repeats, a 21 aa transmembrane segment and a 785 aa cytoplasmic domain that contains six ankyrin repeats, a glutamine-rich domain and a PEST sequence. Notch1 may play an essential role in postimplantation development, probably in some aspect of cell specification and\/or differentiation and may be involved in mesoderm development, somite formation and neurogenesis.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Ala18-Gln526\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 54.4 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 70 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"10μg","offer_id":43072212369587,"sku":"PKSM041299-10","price":163.8,"currency_code":"CAD","in_stock":true},{"title":"50μg","offer_id":43072212402355,"sku":"PKSM041299-50","price":415.8,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_01270096-7923-4c5a-81bd-b7e382939577.png?v=1708684160","url":"https:\/\/afsbio.com\/products\/recombinant-mouse-motch-a-notch1-protein-his-tag-pksm041299","provider":"AFSBio Inc.","version":"1.0","type":"link"}