{"product_id":"recombinant-mouse-nectin-4-c-fc-pksm041375","title":"Recombinant Mouse Nectin-4 (C-Fc) - PKSM041375","description":"\u003cp\u003eRecombinant Mouse Nectin-4 (C-Fc)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10μg, 50μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSM041375-10, PKSM041375-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: Nectin-4\u003c\/p\u003e\n\n\u003cp\u003eTarget Symptom: PVRL4; Nectin-4; Ig superfamily receptor LNIR; Poliovirus receptor-related protein 4; PRR4; LNIR\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Mouse\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: HEK293 Cells\u003c\/p\u003e\n\n\u003cp\u003eApplication: ELISA\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: C-Fc\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: Q8R007\u003c\/p\u003e\n\n\u003cp\u003eAccession: Q8R007\u003c\/p\u003e\n\n\u003cp\u003eBackground: Nectin-4(PVRL4)isatypeItransmembraneglycoproteinwhichbelongstothenectinfamilyofIgsuperfamilyproteins.ItcontainstwoIg-likeC2-typedomainsandoneIg-likeV-typedomain.PVRL4seemstobeinvolvedincelladhesionthroughtrans-homophilicand-heterophilicinteractions, thelatterincludingspecificallyinteractionswithnectin-1.Itdoesnotactasreceptorforalpha-herpesvirusentryintocells.Itispredominantlyexpressedinplacenta, theembryoandbreastcarcinoma.Butitisnotdetectedinnormalbreastepithelium.Thesolubleformisproducedbyproteolyticcleavageatthecellsurface(shedding), probablybyADAM17.Mutationsinthisgenearethecauseofectodermaldysplasia-syndactylysyndrometype 1, an autosomal recessive disorder.\u003c\/p\u003e\n\n\u003cp\u003eActivity: Immobilized Recombinant Mouse Nectin-4 (C-6His)(Cat#PKSM041376) at 10μg\/ml (100 μl\/well) can bind Recombinant Mouse Nectin-4 (C-Fc)(Cat#PKSM041375). The ED50 of PKSM041375 is 0.75 ug\/ml.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Gly31-Ser349\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 61.4 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 75-85 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"10μg","offer_id":43118129807539,"sku":"PKSM041375-10","price":175.0,"currency_code":"CAD","in_stock":true},{"title":"50μg","offer_id":43118129840307,"sku":"PKSM041375-50","price":354.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_eac5e2da-2b35-46ec-b6c2-caf1257cc84a.png?v=1709636758","url":"https:\/\/afsbio.com\/products\/recombinant-mouse-nectin-4-c-fc-pksm041375","provider":"AFSBio Inc.","version":"1.0","type":"link"}