{"product_id":"recombinant-mouse-pcsk9-narc1-protein-his-tag-pksm041128","title":"Recombinant Mouse PCSK9\/NARC1 Protein (His Tag) - PKSM041128","description":"\u003cp\u003eRecombinant Mouse PCSK9\/NARC1 Protein (His Tag)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10μg, 50μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSM041128-10, PKSM041128-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: PCSK9; NARC1\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: Proprotein Convertase Subtilisin\/Kexin Type 9; Neural Apoptosis-Regulated Convertase 1; NARC-1; Proprotein Convertase 9; PC9; Subtilisin\/Kexin-Like Protease PC9; Pcsk9; Narc1; FH3; HCHOLA3; Narc1\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: Q80W65\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Mouse\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: HEK293 Cells\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: C-6His\u003c\/p\u003e\n\n\u003cp\u003eAccession: Q80W65\u003c\/p\u003e\n\n\u003cp\u003eBackground: Proprotein Convertase Subtilisin\/Kexin Type 9 (PCSK9) is a secretory subtilase belonging to the proteinase K subfamily. PCSK9 is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the ER, the pro domain and mature chain secrete together through noncovalent interactions. PCSK9 binds with low-density lipoprotein receptor (LDLR) and plays a major regulatory role in cholesterol homeostasis.PCSK9 also plays a role in neural development.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Gln35-Gln155\u0026amp;Ser156-Gln692\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Supplied as a 0.2 μm filtered solution of 50mM HEPES, 150mM NaCl, 20%Glycerol, pH 7.4.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Not Applicable\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 14\u0026amp;57.4\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 19\u0026amp;60 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at \u0026lt; -20°C, stable for 6 months. Please minimize freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice\/gel packs. Upon receipt, store it immediately at \u0026lt; - 20°C.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"10μg","offer_id":43072203653299,"sku":"PKSM041128-10","price":312.2,"currency_code":"CAD","in_stock":true},{"title":"50μg","offer_id":43072203686067,"sku":"PKSM041128-50","price":830.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_119518b5-5d20-4fc7-8e16-2ebe070f085d.png?v=1708683852","url":"https:\/\/afsbio.com\/products\/recombinant-mouse-pcsk9-narc1-protein-his-tag-pksm041128","provider":"AFSBio Inc.","version":"1.0","type":"link"}