{"product_id":"recombinant-mouse-pleiotrophin-ptn-hb-gam-protein-his-tag-pksm041292","title":"Recombinant Mouse Pleiotrophin\/PTN\/HB-GAM Protein (His Tag) - PKSM041292","description":"\u003cp\u003eRecombinant Mouse Pleiotrophin\/PTN\/HB-GAM Protein (His Tag)\u003c\/p\u003e\n\n\u003cp\u003eSize: 50μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSM041292-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: Pleiotrophin; PTN; HB-GAM\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: Pleiotrophin; PTN; Heparin-binding brain mitogen; HBBM; Heparin-binding growth factor 8; HBGF-8; Osteoblast-specific factor 1; OSF-1; HARP; HB-GAM; HBBN; HBNF; OSF; Osf-1; Osf1\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: P63089\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Mouse\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: HEK293 Cells\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: C-His\u003c\/p\u003e\n\n\u003cp\u003eAccession: P63089\u003c\/p\u003e\n\n\u003cp\u003eBackground: Pleiotrophin (PTN) is an secreted, strongly heparinbinding, developmentally regulated cytokine. PTN and midkine share 50% amino acid (aa) sequence identity, share some functions, and constitute a family. PTN is a highly conserved protein human, mouse, rat, canine, porcine, equine and bovine PTN share 98% aa sequence identity orgreater. During development, PTN is involved in development of brain, bone, and organs undergoing branching morphogenesis. PTN causes PTPRB dimerization and inactivates its phosphatase activity, which allows increased tyrosine phosphorylation of its substrates. Increased expression of PTN is correlated withneuronal development or stresses such as brain ischemia and Parkinson’s disease.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Gly33-Asp168\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 16.1 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 18 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"50μg","offer_id":43072212041907,"sku":"PKSM041292-50","price":366.8,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_554fd581-e2fb-476e-a432-0ab1416b4bdd.png?v=1708684145","url":"https:\/\/afsbio.com\/products\/recombinant-mouse-pleiotrophin-ptn-hb-gam-protein-his-tag-pksm041292","provider":"AFSBio Inc.","version":"1.0","type":"link"}