{"product_id":"recombinant-mouse-progranulin-pgrn-grn-protein-rp02801","title":"Recombinant Mouse Progranulin\/PGRN\/GRN Protein - RP02801","description":"\u003cp\u003eRecombinant Mouse Progranulin\/PGRN\/GRN Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10ug, 20g, 50ug, 100ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RP02801-10, RP02801-20, RP02801-50, RP02801-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Mouse Progranulin\/PGRN\/GRN Protein is produced by HEK293 cells system. The target protein is expressed with sequence (Thr18-Leu589) of Mouse Progranulin\/PGRN\/GRN(Accession #NP_032201.3) fused with His at the C-Terminus.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: Grn, Progranulin, PGRN, Acrogranin, Epithelin\/granulin precursor, GP88, Glycoprotein 88, PC cell-derived growth factor, PCDGF, Proepithelin, PEPI\u003c\/p\u003e\n\n\u003cp\u003eSWISS: P28798\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 14824\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Mouse\u003c\/p\u003e\n\n\u003cp\u003ePurity: ≥ 90% as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20 ℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Granulin family members are important in normal development, wound healing, and tumorigenesis. Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling. Granulin-4 promotes proliferation of the epithelial cell line A431 in culture while granulin-3 acts as an antagonist to granulin-4, inhibiting the growth. Granulin expression inhibited Tat transactivation, and tethering experiments showed that this effect was due, at least in part, to a direct action on cyclin T1 in the absence of Tat.\u003c\/p\u003e\n\n\u003cp\u003eSource: HEK293 cells\u003c\/p\u003e\n\n\u003cp\u003eTag: C-6His\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).\u003c\/p\u003e\n\n\u003cp\u003eAntigen Sequence: TQCPDGQFCPVACCLDQGGANYSCCNPLLDTWPRITSHHLDGSCQTHGHCPAGYSCLLTVSGTSSCCPFSKGVSCGDGYHCCPQGFHCSADGKSCFQMSDNPLGAVQCPGSQFECPDSATCCIMVDGSWGCCPMPQASCCEDRVHCCPHGASCDLVHTRCVSPTGTHTLLKKFPAQKTNRAVSLPFSVVCPDAKTQCPDDSTCCELPTGKYGCCPMPNAICCSDHLHCCPQDTVCDLIQSKCLSKNYTTDLLTKLPGYPVKEVKCDMEVSCPEGYTCCRLNTGAWGCCPFAKAVCCEDHIHCCPAGFQCHTEKGTCEMGILQVPWMKKVIAPLRLPDPQILKSDTPCDDFTRCPTNNTCCKLNSGDWGCCPIPEAVCCSDNQHCCPQGFTCLAQGYCQKGDTMVAGLEKIPARQTTPLQIGDIGCDQHTSCPVGQTCCPSLKGSWACCQLPHAVCCEDRQHCCPAGYTCNVKARTCEKDVDFIQPPVLLTLGPKVGNVECGEGHFCHDNQTCCKDSAGVWACCPYLKGVCCRDGRHCCPGGFHCSARGTKCLRKKIPRWDMFLRDPVPRPLL\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 0.01 EU\/μg of the protein by LAL method.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"10ug","offer_id":45198273446067,"sku":"RP02801-10","price":196.0,"currency_code":"CAD","in_stock":true},{"title":"20ug","offer_id":45198273478835,"sku":"RP02801-20","price":266.0,"currency_code":"CAD","in_stock":true},{"title":"50ug","offer_id":45198273511603,"sku":"RP02801-50","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"100ug","offer_id":45198273544371,"sku":"RP02801-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_0468eaaa-d2f4-479b-a3b3-ca22d0d6affe.png?v=1766959982","url":"https:\/\/afsbio.com\/products\/recombinant-mouse-progranulin-pgrn-grn-protein-rp02801","provider":"AFSBio Inc.","version":"1.0","type":"link"}