{"product_id":"recombinant-mouse-r-spondin-1-rspo1-protein-rp01807","title":"Recombinant Mouse R-spondin-1\/RSPO1 Protein - RP01807","description":"\u003cp\u003eRecombinant Mouse R-spondin-1\/RSPO1 Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10ug, 20g, 50ug, 100ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RP01807-10, RP01807-20, RP01807-50, RP01807-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Mouse R-spondin-1\/RSPO1 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ser21-Gln265) of mouse R-spondin-1\/RSPO (Accession #NP_619624.2) fused with 6×His tag at the C-terminus.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: Rspondin; R-spondin; RSPO1\u003c\/p\u003e\n\n\u003cp\u003eSWISS: Q9Z132\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 192199\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Mouse\u003c\/p\u003e\n\n\u003cp\u003ePurity: ≥ 95 % as determined by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20 ℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\n\u003cp\u003eBackground: RSPO1 gene is a member of the R-spondin family. It encodes RSPO1 which is known as a secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, RSPO1 induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects. This protein is an activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. RSPO1 acts both in the canonical Wnt\/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway, probably by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. It also acts as a ligand for frizzled FZD8 and LRP6.\u003c\/p\u003e\n\n\u003cp\u003eSource: HEK293 cells\u003c\/p\u003e\n\n\u003cp\u003eTag: C-His\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.\u003c\/p\u003e\n\n\u003cp\u003eAntigen Sequence: SRGIKGKRQRRISAEGSQACAKGCELCSEVNGCLKCSPKLFILLERNDIRQVGVCLPSCPPGYFDARNPDMNKCIKCKIEHCEACFSHNFCTKCQEALYLHKGRCYPACPEGSTAANSTMECGSPAQCEMSEWSPWGPCSKKRKLCGFRKGSEERTRRVLHAPGGDHTTCSDTKETRKCTVRRTPCPEGQKRRKGGQGRRENANRHPARKNSKEPRSNSRRHKGQQQPQPGTTGPLTSVGPTWAQ\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 0.01 EU\/μg of the protein by LAL method\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"10ug","offer_id":45198260437171,"sku":"RP01807-10","price":210.0,"currency_code":"CAD","in_stock":true},{"title":"20ug","offer_id":45198260469939,"sku":"RP01807-20","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"50ug","offer_id":45198260502707,"sku":"RP01807-50","price":350.0,"currency_code":"CAD","in_stock":true},{"title":"100ug","offer_id":45198260535475,"sku":"RP01807-100","price":560.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_bf4e44d8-7122-4fad-88b8-7256d31ca0d0.png?v=1766959844","url":"https:\/\/afsbio.com\/products\/recombinant-mouse-r-spondin-1-rspo1-protein-rp01807","provider":"AFSBio Inc.","version":"1.0","type":"link"}