{"product_id":"recombinant-mouse-rankl-tnfsf11-protein-his-tagactive-pksm041165","title":"Recombinant Mouse RANKL\/TNFSF11 Protein (His Tag)(Active) - PKSM041165","description":"\u003cp\u003eRecombinant Mouse RANKL\/TNFSF11 Protein (His Tag)(Active)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10μg, 50μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSM041165-10, PKSM041165-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: RANKL; TNFSF11\u003c\/p\u003e\n\n\u003cp\u003eTarget Symptom: Tumor necrosis factor ligand superfamily member 11; Tnfsf11; Osteoclast differentiation factor; ODF; Osteoprotegerin ligand; OPGL; Receptor activator of nuclear factor kappa-B ligand; RANKL; TNF-related activation-induced cytokine; TRANCE; CD254\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Mouse\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: HEK293 Cells\u003c\/p\u003e\n\n\u003cp\u003eApplication: ELISA\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: C-6His\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: O35235\u003c\/p\u003e\n\n\u003cp\u003eAccession: O35235\u003c\/p\u003e\n\n\u003cp\u003eBackground: Mouse tumor necrosis factor ligand superfamily member 11(Tnfsf11) is a member of the tumor necrosis factor (TNF) cytokine family. Tnfsf11 is widely expressed in cells including T cells and T cell rich organs, such as thymus and lymph nodes. This cytokine can bind to TNFRSF11B\/OPG andTNFRSF11A\/RANK. Tnfsf11 is involved in a number of fundamental biological processes such as acting as regulator of interactions between T-cells and dendritic cells, the regulation of the T-cell-dependent immune response and enhancing bone-resorption in humoral hypercalcemia of malignancy. It augments the ability of dendritic cells to stimulate naive T-cell proliferation.\u003c\/p\u003e\n\n\u003cp\u003eActivity: Immobilized Human OPG-Fc(Cat: PKSH033124) at 2μg\/ml(100 μl\/well) can bind Mouse RANKL-His. The ED50 of Mouse RANK L-His is 2. 44ug\/ml.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Ala73-Asp316\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 28.5 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 30-35 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"10μg","offer_id":43118125678771,"sku":"PKSM041165-10","price":249.2,"currency_code":"CAD","in_stock":true},{"title":"50μg","offer_id":43118125711539,"sku":"PKSM041165-50","price":732.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_7f36d6f1-accf-4f69-b82a-e34bcdde0f51.png?v=1709636707","url":"https:\/\/afsbio.com\/products\/recombinant-mouse-rankl-tnfsf11-protein-his-tagactive-pksm041165","provider":"AFSBio Inc.","version":"1.0","type":"link"}