{"product_id":"recombinant-mouse-rat-flt4-ligand-vegf-c-protein-rp02804","title":"Recombinant Mouse\/Rat Flt4 ligand\/VEGF-C Protein - RP02804","description":"\u003cp\u003eRecombinant Mouse\/Rat Flt4 ligand\/VEGF-C Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10ug, 20g, 50ug, 100ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RP02804-10, RP02804-20, RP02804-50, RP02804-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Mouse\/Rat VEGF-C Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ala108-Arg223) of mouse\/rat VEGF-C (Accession #NP_033532.1) fused with a 6×His tag at the C-terminus.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: VEGFC, Flt4-L, LMPH1D, VRP; VEGF-C\u003c\/p\u003e\n\n\u003cp\u003eSWISS: P97953\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 22341\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Mouse\/Rat\u003c\/p\u003e\n\n\u003cp\u003ePurity: ≥ 95 % as determined by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20 ℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Vascular endothelial growth factor C (VEGF-C) is a member of the VEGF family. Upon biosynthesis, VEGF-C protein is secreted as a non-covalent momodimer in an anti-parellel fashion. VEGF-C protein is a dimeric glycoprotein, as a ligand for two receptors, VEGFR-3 (Flt4), and VEGFR-2. VEGF-C may function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis. VEGF-C protein is over-expressed in various human cancers including breast cancer and prostate cancer. VEGF-C\/VEGFR-3 axis, through different signaling pathways, plays a critical role in cancer progression by regulating different cellular functions, such as invasion, proliferation, and resistance to chemotherapy. Thus, targeting the VEGF-C\/VEGFR-3 axis may be therapeutically significant for certain types of tumors.\u003c\/p\u003e\n\n\u003cp\u003eBio-Activity: Measured by its binding ability in a functional ELISA. Immobilized Mouse\/Rat VEGF-C (Catalog: RP02804) at 2 μg\/mL (100 μL\/well) can bind Human VEGFR-3\/FLT-4 (Catalog: RP00123) with a linear range of 0.0085-7.49 ng\/mL.\u003c\/p\u003e\n\n\u003cp\u003eSource: HEK293 cells\u003c\/p\u003e\n\n\u003cp\u003eTag: C-His\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.\u003c\/p\u003e\n\n\u003cp\u003eAntigen Sequence: AHYNTEILKSIDNEWRKTQCMPREVCIDVGKEFGAATNTFFKPPCVSVYRCGGCCNSEGLQCMNTSTGYLSKTLFEITVPLSQGPKPVTISFANHTSCRCMSKLDVYRQVHSIIRR\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 0.01 EU\/μg of the protein by LAL method\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"10ug","offer_id":45198341505203,"sku":"RP02804-10","price":168.0,"currency_code":"CAD","in_stock":true},{"title":"20ug","offer_id":45198341537971,"sku":"RP02804-20","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"50ug","offer_id":45198341570739,"sku":"RP02804-50","price":420.0,"currency_code":"CAD","in_stock":true},{"title":"100ug","offer_id":45198341603507,"sku":"RP02804-100","price":672.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_395c9008-9325-4ddf-b770-291323135bfd.png?v=1766960810","url":"https:\/\/afsbio.com\/products\/recombinant-mouse-rat-flt4-ligand-vegf-c-protein-rp02804","provider":"AFSBio Inc.","version":"1.0","type":"link"}