{"product_id":"recombinant-mouse-ren1-renin-1-protein-his-tag-pksm041281","title":"Recombinant Mouse REN1\/Renin-1 Protein (His Tag) - PKSM041281","description":"\u003cp\u003eRecombinant Mouse REN1\/Renin-1 Protein (His Tag)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10μg, 50μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSM041281-10, PKSM041281-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: REN1; Renin-1\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: Renin-1; Angiotensinogenase; Kidney renin; Ren1; Ren; Ren-1; Angiotensin-forming enzyme; Ren-A; Ren1c; Ren1d; Rn-1; Rnr\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: P06281\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Mouse\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: HEK293 Cells\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: C-His\u003c\/p\u003e\n\n\u003cp\u003eAccession: P06281\u003c\/p\u003e\n\n\u003cp\u003eBackground: Mouse Renin, also known as Renin-1, is a member of the peptidase A1 amily. Renin is synthesized by the juxtaglomerular cells of the kidney in response to decreased blood pressure and sodium concentration. It cleaves angiotensinogen to generate angiotensin I, which can be further converted by angiotensin converting enzyme (ACE) to angiotensin II. Angiotensin II is the active molecule of the reninangiotensin system that acts by binding to angiotensin receptors type 1 and 2 (AT1 and AT2), and has direct pathophysiological effects on the heart and peripheral vasculature. After secretion, inactive prorenin can be proteolytically activated by trypsin, cathepsin B, or other proteinases.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Leu22-Arg402\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 43.5 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 50-60 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"10μg","offer_id":43072211484851,"sku":"PKSM041281-10","price":155.4,"currency_code":"CAD","in_stock":true},{"title":"50μg","offer_id":43072211517619,"sku":"PKSM041281-50","price":415.8,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_327da525-e758-4781-8c2e-6cde41049aac.png?v=1708684123","url":"https:\/\/afsbio.com\/products\/recombinant-mouse-ren1-renin-1-protein-his-tag-pksm041281","provider":"AFSBio Inc.","version":"1.0","type":"link"}