{"product_id":"recombinant-mouse-sirpa-cd172a-protein-fc-tag-pksm041145","title":"Recombinant Mouse SIRPA\/CD172a Protein (Fc Tag) - PKSM041145","description":"\u003cp\u003eRecombinant Mouse SIRPA\/CD172a Protein (Fc Tag)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10μg, 50μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSM041145-10, PKSM041145-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: SIRPA; CD172a\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: Tyrosine-Protein Phosphatase Non-Receptor Type Substrate 1; CD172 Antigen-Like Family Member A; Signal-Regulatory Protein Alpha-1; CD172a; SIRPA; MFR; SHPS1; SIRP\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: Q6P6I8\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Mouse\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: HEK293 Cells\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: C-Fc\u003c\/p\u003e\n\n\u003cp\u003eAccession: Q6P6I8\u003c\/p\u003e\n\n\u003cp\u003eBackground: Mouse Signal Regulatory Protein α (SIRPα) is a type I transmembrane glycoprotein.It contains two Ig-like C1-type domains and one Ig-like V-type domain. Mouse SIRP alpha ECD shares 61%, 75%, 62%, 61%, and 59% aa sequence identity with human, rat, equine, bovine, and porcine SIRP alpha, respectively.SIRPα can express in various tissues, mainly on brain and myeloid cells, including macrophages, neutrophils, dendritic and Langerhans cells. It also can detect in neurons, smooth muscle and endothelial cells. SIRPA is an immunoglobulin-like cell surface receptor for CD47. SIRPα acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPα shows adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. SIRPα engagement generally produces a negative regulatory signal; it may mediate negative regulation of phagocytosis, mast cell activation and dendritic cell activation\u003c\/p\u003e\n\n\u003cp\u003eSequence: Lys32-Asn372\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 65.1 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 115-125 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"10μg","offer_id":43072204701875,"sku":"PKSM041145-10","price":163.8,"currency_code":"CAD","in_stock":true},{"title":"50μg","offer_id":43072204734643,"sku":"PKSM041145-50","price":415.8,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_fe684496-bf69-44ee-bbf8-4602b69c4c35.png?v=1708683893","url":"https:\/\/afsbio.com\/products\/recombinant-mouse-sirpa-cd172a-protein-fc-tag-pksm041145","provider":"AFSBio Inc.","version":"1.0","type":"link"}