{"product_id":"recombinant-mouse-thrombomodulin-c-6his-ept230","title":"Recombinant Mouse Thrombomodulin (C-6His) - EPT230","description":"\u003cp\u003eRecombinant Mouse Thrombomodulin (C-6His)\u003c\/p\u003e\n\n\u003cp\u003eSize: 10ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: EPT230-10\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Thrombomodulin is also known as CD141 antigen and blood dendritic cell antigen 3 (BDCA3), which is encoded by the THBD gene. The deduced amino acid sequence of mouse THBD predicts a signal peptide (aa 1 to 16) and a mature chain (aa 17 to 577) that consists of the following domains: C-type lectin, EGF-like, transmembrane and cytoplasmic. Mouse THBD is corresponding to the extracellular portion of the type I membrane protein. Predominantly synthesized by vascular endothelial cells, THBD inhibits coagulation and fibrinolysis. It functions as a cell surface receptor and an essential cofactor for active thrombin, which in turn activates protein C and thrombinactivatable fibrinolysis inhibitor (TAFI), also known as carboxypeptidase B2 (CPB2). In addition, THBD gene polymorphisims are associated with human disease and THBD plays a role in thrombosis, stroke, arteriosclerosis, and cancer.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: Thrombomodulin; TM; Fetomodulin; CD141; BDCA-3; Thbd\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Mouse Thrombomodulin is produced by our Mammalian expression system and the target gene encoding Leu17-Ser517 is expressed with a 6His tag at the C-terminus.\u003c\/p\u003e\n\n\u003cp\u003eAccession: P15306\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight: 54.6 KDa\u003c\/p\u003e\n\n\u003cp\u003eApparent Molecular Weight: 85-90 KDa, reducing conditions\u003c\/p\u003e\n\n\u003cp\u003eStorage Condition: Lyophilized protein should be stored at \u0026lt; -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20°C for 3 months.\u003c\/p\u003e\n\n\u003cp\u003ePurity: Greater than 95% as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: Less than 0.1 ng\/µg (1 EU\/µg) as determined by LAL test.\u003c\/p\u003e\n\n\u003cp\u003eDelivery Condition: The product is shipped on dry ice\/polar packs. Upon receipt, store it immediately at the temperature listed below.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.\u003c\/p\u003e \n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Bio","offers":[{"title":"Default Title","offer_id":43211047239859,"sku":"EPT230-10","price":390.6,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_360x_55ed21bf-69f9-4a6b-8294-e200823a6f92.png?v=1767117551","url":"https:\/\/afsbio.com\/products\/recombinant-mouse-thrombomodulin-c-6his-ept230","provider":"AFSBio Inc.","version":"1.0","type":"link"}