{"product_id":"recombinant-mouse-tnfrsf9-4-1bb-cd137-protein-rp01560","title":"Recombinant Mouse TNFRSF9\/4-1BB\/CD137 Protein - RP01560","description":"\u003cp\u003eRecombinant Mouse TNFRSF9\/4-1BB\/CD137 Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10ug, 20g, 50ug, 100ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RP01560-10, RP01560-20, RP01560-50, RP01560-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Mouse TNFRSF9\/4-1BB\/CD137 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Val24-Leu211) of mouse TNFRSF9\/4-1BB\/CD137 (Accession #NP_001070976.1) fused with a hFc tag at the C-terminus.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: 4-1BB , CD137 , CDw137 , ILA, TNFRSF9, 4-1BB , CD137 , CDw137 , ILA, TNFRSF9\u003c\/p\u003e\n\n\u003cp\u003eSWISS: Q8R037\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 21942\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Mouse\u003c\/p\u003e\n\n\u003cp\u003ePurity: ≥ 95 % as determined by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20 ℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\n\u003cp\u003eBackground: CD137 (also known as 4-1BB) is a surface co-stimulatory glycoprotein originally described as present on activated T lymphocytes, which belongs to the tumor necrosis factor (TNF) receptor superfamily. It is expressed mainly on activated CD4+ and CD8+ T cells, and binds to a high-affinity ligand (4-1BBL) expressed on several antigen-presenting cells such as macrophages and activated B cells. Upon ligand binding, 4-1BB is associated with the tumor necrosis factor receptor–associated factors (TRAFs), the adaptor protein which mediates downstream signaling events including the activation of NF-kappaB and cytokine production. 4-1BB signaling either by binding to 4-1BBL or by antibody ligation delivers signals for T-cell activation and growth, as well as monocyte proliferation and B-cell survival, and plays an important role in the amplification of T cell-mediated immune responses.\u003c\/p\u003e\n\n\u003cp\u003eBio-Activity: Measured by its binding ability in a functional ELISA. Immobilized Mouse TNFSF9(Catalog: RP00766) at 5μg\/mL (100 μL\/well) can bind Mouse TNFRSF9\/4-1BB\/CD137(Catalog: RP01560) with a linear range of 0.005-1.41 ng\/mL.\u003c\/p\u003e\n\n\u003cp\u003eSource: HEK293 cells\u003c\/p\u003e\n\n\u003cp\u003eTag: C-hFc\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.\u003c\/p\u003e\n\n\u003cp\u003eAntigen Sequence: VQNSCDNCQPGTFCRKYNPVCKSCPPSTFSSIGGQPNCNICRVCAGYFRFKKFCSSTHNAECECIEGFHCLGPQCTRCEKDCRPGQELTKQGCKTCSLGTFNDQNGTGVCRPWTNCSLDGRSVLKTGTTEKDVVCGPPVVSFSPSTTISVTPEGGPAFKKTTGAAQEEDACSCRCPQEEEGGGGGYEL\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1 EU\/μg of the protein by LAL method.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"10ug","offer_id":45198322335923,"sku":"RP01560-10","price":182.0,"currency_code":"CAD","in_stock":true},{"title":"20ug","offer_id":45198322368691,"sku":"RP01560-20","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"50ug","offer_id":45198322401459,"sku":"RP01560-50","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"100ug","offer_id":45198322434227,"sku":"RP01560-100","price":420.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_2ec0100b-3073-4404-a482-0bd80764801c.png?v=1766960593","url":"https:\/\/afsbio.com\/products\/recombinant-mouse-tnfrsf9-4-1bb-cd137-protein-rp01560","provider":"AFSBio Inc.","version":"1.0","type":"link"}