{"product_id":"recombinant-mouse-trkc-ntrk3-c-6his-pksm041444","title":"Recombinant Mouse TrkC\/Ntrk3 (C-6His) - PKSM041444","description":"\u003cp\u003eRecombinant Mouse TrkC\/Ntrk3 (C-6His)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10μg, 50μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSM041444-10, PKSM041444-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: TrkC; Ntrk3\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: GP145-TrkC; TrkC; trk-C; Neurotrophic tyrosine kinase receptor type 3; TrkC tyrosine kinase; NT-3 Growth Factor Receptor\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: Q6VNS1\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Mouse\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: HEK293 Cells\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: C-6His\u003c\/p\u003e\n\n\u003cp\u003eAccession: Q6VNS1\u003c\/p\u003e\n\n\u003cp\u003eBackground: Three Trk family proteins, TrkA, TrkB, and TrkC, exhibiting different ligand specificities, have been identified. TrkA binds NGF and NT-3, TrkB binds BDNF, NT-3 and NT-4\/5, and TrkC only binds NT-3. The primary location of TrkC expression is in the nervous system and, specifically, in regions of the CNS. Low level TrkC expression has also been observed in a wide variety of tissues outside the nervous system. Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3\/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase\/AKT and the MAPK pathways, that control cell survival and differentiation.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Cys32-Thr429\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 45.5 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 80-110 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"10μg","offer_id":43072224362675,"sku":"PKSM041444-10","price":226.8,"currency_code":"CAD","in_stock":true},{"title":"50μg","offer_id":43072224395443,"sku":"PKSM041444-50","price":679.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_748f1598-320c-4f4d-b021-3a04c5edd860.png?v=1708684573","url":"https:\/\/afsbio.com\/products\/recombinant-mouse-trkc-ntrk3-c-6his-pksm041444","provider":"AFSBio Inc.","version":"1.0","type":"link"}