{"product_id":"recombinant-mouse-trop2-tacstd2-protein-his-tagactive-pksm040435","title":"Recombinant Mouse TROP2\/TACSTD2 Protein (His Tag)(Active) - PKSM040435","description":"Recombinant Mouse TROP2\/TACSTD2 Protein (His Tag)(Active)\n\nSize: 100μg\n\nCatalogue Number: PKSM040435-100\n\nCitations, Manuals and MSDS Available upon request.\n\nAbbreviation: TROP2; TACSTD2\n\nTarget Symptom: Tumor-associated calcium signal transducer 2; Tacstd2; Trop2; Cell surface glycoprotein Trop-2; TROP-2; C80403; EGP-1; GA733-1; Ly97\n\nTarget Species: Mouse\n\nExpression Host: HEK293 Cells\n\nApplication: Cell culture; ELISA\n\nFusion Tag: C-His\n\nUNIProt ID: Q8BGV3\n\nAccession: Q8BGV3\n\nBackground: TROP-2, also referred to as tumor associated calcium signal transducer 2 (TACSTD2), GA733-1 or M1S1, is a cell surface glycoprotein highly expressed in a wide variety of epithelial cancers. In contrast, there is little or no expression of Trop-2 in adult somatic tissue. Because it is a cell surface protein that is selectively expressed in tumor cells, Trop-2 is a potential therapeutic target. The cytoplasmic tail of Trop-2 possesses potential serine and tyrosine phosphorylation sites and a phosphatidyl-inositol binding consensus sequence. Trop-2 transduces an intracellular calcium signal, are consistent with the hypothesis that it acts as a cell surface receptor and support a search for a physiological ligand. TROP2 encoding by an intronless gene was originally defined by the monoclonal antibody GA733, and is a member of a family of at least two type I membrane proteins. The other known member is GA733-2, also called EpCAM and TROP1. It has been suggested by studies that the GA733-1 gene was formed by the retroposition of the GA733-2 gene via an mRNA intermediate.\n\nActivity: Measured by the ability of the immobilized protein to support the adhesion of U937 human histiocytic lymphoma cells. When 5 x 10\u003csup\u003e4\u003c\/sup\u003e cells\/well are added to TACSTD2-coated plates (40 μg\/mL, 100 μL\/well), \u0026gt; 50% cells will adhere after 1 hour at 37℃.\n\nSequence: Met 1-Gln 270\n\nPurity: \u0026gt; 92 % as determined by reducing SDS-PAGE.\n\nFormulation: Lyophilized from sterile PBS, pH 7.4\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\nPlease refer to the specific buffer information in the printed manual.\n\nReconstitution: Please refer to the printed manual for detailed information.\n\nEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\n\nCalculated MW: 29.4 kDa\n\nObserved MW: 45 kDa\n\nStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\n\nShipping: This product is provided as lyophilized powder which is shipped with ice packs.\n\nResearch Use Only","brand":"Elabscience","offers":[{"title":"Default Title","offer_id":43104356663475,"sku":"PKSM040435-100","price":635.6,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_0403f05d-eeb2-41a2-810c-7c9b2df75174.png?v=1709295140","url":"https:\/\/afsbio.com\/products\/recombinant-mouse-trop2-tacstd2-protein-his-tagactive-pksm040435","provider":"AFSBio Inc.","version":"1.0","type":"link"}