{"product_id":"recombinant-murine-interleukin-10-rmuil-10-pr2021","title":"Recombinant Murine Interleukin-10 (rMuIL-10) - PR2021","description":"\u003cp\u003eRecombinant Murine Interleukin-10 (rMuIL-10)\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PR2021-2, PR2021-10\u003c\/p\u003e\n\n\u003cp\u003eSizes: 2µg, 10µg\u003c\/p\u003e\n\n\u003cp\u003eSource: Escherichia coli\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight: Approximately 18.7 kDa, a single non-glycosylated polypeptide chain containing 161 amino acids\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt;97% by SDS-PAGE and HPLC analyses.\u003c\/p\u003e\n\n\u003cp\u003eBiological Activity: Fully biologically active when compared to standard. The ED50 as determined by the dose-dependent co-stimulation (with IL-4) of the proliferation of murine MC\/9 cells was found to be \u0026lt; 2 ng\/ml, corresponding to a specific activity of \u0026gt; 5 x 105 units\/mg.\u003c\/p\u003e\n\n\u003cp\u003ePhysical Appearance: Sterile Filtered White lyophilized (freeze-dried) powder.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.2mm filtered concentrated solution in PBS, pH 7.4.\u003c\/p\u003e\n\n\u003cp\u003eAA Sequence: MSRGQYSRED NNCTHFPVGQ SHMLLELRTA FSQVKTFFQT KDQLDNILLT\u003cbr\u003e\n DSLMQDFKGY LGCQALSEMI QFYLVEVMPQ AEKHGPEIKE HLNSLGQKLK\u003cbr\u003e\n TLRMRLRRCH RFLPCENKSK AVEQVKSDFN KLEDQGVYKA MNEFDIFINC\u003cbr\u003e\n IEAYMMIKMK S\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: Less than 1EU\/mg of rMuIL-10 as determined by LAL method.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg\/ml. Stock solutions should be apportioned into working aliquots and stored at \u0026lt;-20°C. Further dilutions should be made in appropriate buffered solutions.\u003c\/p\u003e\n\n\u003cp\u003eStorage: This lyophilized preparation is stable at 2-8°C, but should be kept at -20°C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8°C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20°C to -70°C. Avoid repeated freeze\/thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eUsage: This material is offered by USA Bioworld biotech for research, laboratory or further evaluation purposes. NOT FOR HUMAN USE. Made in China\u003c\/p\u003e\n\n\u003cp\u003eDescription: IL-10 is an immunosuppressive cytokine produced by a variety of mammalian cell types including macrophages, monocytes, T cells, B cells and keratinocytes. IL-10 inhibits the expression of proinflammatory cytokines such as IL-1 and TNFα. Like IL-4, IL-10 enhances humoral immune responses and attenuates cell-mediated immune reactions. Human IL-10 active on murine cells, but murine IL-10 is inactive on human cells.\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"2µg","offer_id":42882221867187,"sku":"PR2021-2","price":260.23,"currency_code":"CAD","in_stock":true},{"title":"10µg","offer_id":42882221899955,"sku":"PR2021-10","price":490.83,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_08515674-ed87-4194-83eb-ff3df48bcb4d.jpg?v=1702049531","url":"https:\/\/afsbio.com\/products\/recombinant-murine-interleukin-10-rmuil-10-pr2021","provider":"AFSBio Inc.","version":"1.0","type":"link"}